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Epidemiology of Depression and Heart Failure in Aging

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00241761
First Posted: October 19, 2005
Last Update Posted: August 8, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
  Purpose
To understand how depression leads to congestive heart failure (CHF) in older adults.

Condition
Cardiovascular Diseases Heart Diseases Heart Failure Heart Failure, Congestive Depression Coronary Disease

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: September 2005
Study Completion Date: August 2010
Detailed Description:

BACKGROUND:

Depression is known to be associated with an increased risk of coronary heart disease (CHD), and with adverse outcomes among older adults with CHD. Recent evidence suggests that depression is also associated with an increased risk of congestive heart failure, and with adverse outcomes among older adults with congestive heart failure. However, the mechanisms by which depression leads to congestive heart failure are not known

DESIGN NARRATIVE:

To determine the mechanisms of association between depression and CHF, the investigators will use an existing cohort of 1024 older adults (mean age 67) with CHD (including 680 with no heart failure and 344 with clinical or subclinical heart failure) who were recruited between September 2000 and December 2002 for "The Heart and Soul Study." The Heart and Soul Study was originally designed to understand the mechanism of association between depression and CHD. Since patients with CHD are at high risk for CHF, this well-characterized cohort will provide a unique opportunity to examine the relation between depression and CHF. At baseline, participants completed a depression interview (Diagnostic Interview Schedule); full exercise treadmill testing with stress echocardiography; 24-hour Holter monitoring for heart rate variability; 24-hour urine collection for cortisol and norepinephrine; venous blood measurements for lipids, platelet reactivity, and C-reactive protein; and an extensive questionnaire. Participants have been followed annually by telephone. The investigators will invite all participants to return for a 5-year examination, and will follow them for an additional 3 years thereafter, to determine (a) the independent association between baseline depression and CHF, and (b) the extent to which 5-vear changes in biological and behavioral factors associated with depression explain the relation between depression and CHF. By identifying the mechanisms that explain the relation between depression and CHF, this study will enable them to target specific areas for improving the treatment of these patients.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
No eligibility criteria
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00241761


Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
OverallOfficial: Mary Whooley Northern California Institute for Res & Educ
  More Information

ClinicalTrials.gov Identifier: NCT00241761     History of Changes
Other Study ID Numbers: 1312
R01HL079235-04 ( U.S. NIH Grant/Contract )
First Submitted: October 17, 2005
First Posted: October 19, 2005
Last Update Posted: August 8, 2016
Last Verified: April 2012

Additional relevant MeSH terms:
Depression
Depressive Disorder
Heart Failure
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Behavioral Symptoms
Mood Disorders
Mental Disorders
Myocardial Ischemia
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases