Vaporization as a Smokeless Cannabis Delivery System
A study to evaluate the use of a vaporization system as a smokeless delivery system for inhaled marijuana.
|Study Design:||Allocation: Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||Vaporization as a Smokeless Cannabis Delivery System: A Pilot Study|
- To assess the delivery of cannabinoids and metabolites by way of vaporization and to compare plasma levels to those obtained from smoking an identical amount of marijuana from a cigarette.
|Study Start Date:||August 2004|
|Estimated Study Completion Date:||May 2005|
Our primary objective is to evaluate the use of a vaporization system ( the Volcano) as a smokeless delivery system for inhaled marijuana. We will compare plasma levels of delta-9-tetrahydrocannabinol (THC), cannabinol, cannabidiol, and metabolites, including 11-OH-THC, in healthy volunteers after smoking ~400 mg each of approximately 1.8, 3.5, and 7% THC marijuana cigarettes (using the Foltin puff procedure) to those obtained when the same individuals inhale the vaporization product of the rest of the marijuana from the identical cigarette processed through the Volcano device. In addition to plasma levels, we will also compare the THC concentrations over an 8-hour time period, the subjective high experienced by the patients, and clinical evidence of cannabis effect by evaluating conjunctival hyperemia and heart rate. We will also compare the tolerability of the two methods of ingestion, and we will monitor expired carbon monoxide to evaluate whether the vaporizer reduces exposure to respiratory toxins.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00241592
|United States, California|
|UCSF Community Consortium|
|San Francisco, California, United States, 94110|
|Principal Investigator:||Donald I Abrams, M.D.||UCSF Community Consortium|