Study of High Density Lipoprotein Cholesterol (HDL-C)-Raising Mechanism of Rosuvastatin (CRESTOR™) by Quantifying the Key Steps of Reverse Cholesterol Transport (RCT)
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|ClinicalTrials.gov Identifier: NCT00240266|
Recruitment Status : Completed
First Posted : October 18, 2005
Last Update Posted : November 19, 2010
|Condition or disease||Intervention/treatment||Phase|
|Metabolic Syndrome Dyslipidemia||Drug: Rosuvastatin||Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||15 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||A Randomised, Double-blind, Placebo-controlled, Crossover Pilot Study to Define the High Density Lipoprotein Cholesterol (HDL-C)-Raising Mechanism of Rosuvastatin (CRESTOR™) by Quantifying the Key Steps of Reverse Cholesterol Transport (RCT)|
|Study Start Date :||August 2003|
|Actual Primary Completion Date :||November 2004|
|Actual Study Completion Date :||December 2004|
- Determine the effect of treatment with rosuvastatin on the capacity of plasma to promote cholesterol efflux, which is the first and likely rate limiting step in reverse cholesterol transport.
- Determine the effect of treatment with rosuvastatin on:
- - cholesterol esterification by measuring plasma lecithin:cholesterol acyl transferase concentration and capacity to esterify cholesterol, one of the stops in RCT.
- - plasma concentration of cholesterol ester transfer protein and capacity to transfer cholesterol from HDL-C to apoB-containing lipoproteins, one of the steps in RCT.
- - plasma concentration of preβ1-HDL.
- - plasma concentration of LDL cholesterol, HDL-C and apoA-1.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00240266
|Melbourne, Victoria, Australia|
|Principal Investigator:||Paul J Nestel, MD||Baker Heart Research Institute|