A Study of Omega-3 as a Treatment for Major Depression
Recruitment status was Recruiting
The purpose of this study is to determine whether omega-3 polyunsaturated fatty acids are effective as a monotherapy for depression.
Drug: Omega-3 Polyunsaturated Fatty Acids
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||A Randomised, Double-Blind, Placebo Controlled Trial of Omega-3 Polyunsaturated Fatty Acids as a Monotherapy for Major Depression|
- Change from pretreatment score on Depression Rating Scale at 6 weeks.
- Weekly measure of depressive symptoms
- Weekly measure of anxiety symptoms
- Weekly measure of functional status
|Study Start Date:||October 2005|
The study will be a 6 week, parallel-group, double-blind randomized controlled trial of the efficacy of Omega-3 as a monotherapy for depression. People aged 21-65 who have major depression but are not currently on an antidepressant or planning to take an antidepressant in the next 14 weeks will be recruited. Participants will be randomly allocated to receive Omega-3 (fish oil) or placebo (paraffin oil) for 6 weeks. Participants will be followed up weekly and will be asked to rate their mood daily for the 6 week study period. Blood samples will be taken pre and post treatment to measure change in omega-3 levels. At the end of 6 weeks all participants will receive a further 8 weeks supply of omega-3.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00238758
|Contact: Catherine Owen, Bsc (hons)||+ 61 2 9382 firstname.lastname@example.org|
|Australia, New South Wales|
|The University of New South Wales/ Black Dog Institute||Recruiting|
|Sydney, New South Wales, Australia, 2031|
|Contact: Catherine Owen, Bsc (hons) 02 9382 4521 email@example.com|
|Principal Investigator:||Anne Marie Rees, BSc MBBS||Senior Research Fellow and Consultant Psychiatrist, School of Psychiatry, UNSW & Black Dog Institute|
|Study Director:||Gordon B Parker, Dsc MD PhD||Professor, School of Psychiatry UNSW and Executive Director, Black Dog Institute|