Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea
This is a research study of asthma and sleep apnea. Our hypothesis is that untreated sleep apnea causes inflammation in the lung, which can worsen asthma. We believe treatment of sleep apnea will reduce this inflammation, and improve asthma control. This study will help us better understand what happens to the lung and bronchial tubes before and after treatment of sleep apnea, which could benefit all patients with sleep apnea. This study involves 2 bronchoscopies.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effect of CPAP (Continuous Positive Airway Pressure) on Airway Inflammation in Asthmatics With Sleep-Disordered Breathing: A Pilot Study|
- Systemic inflammatory markers will include IL-6, IL-8, CRP, and TNF-α.
- Exhaled breath condensate levels of IL-6 and 8-isporostane will be measured.
- BAL (bronchial lavage) fluid cell count and differential, IL-6, IL-8, and TNF- α will be measured.
- Endobronchial biopsies to analyze extent and type of inflammatory cell.
- Symptoms, albuterol use and daily morning and evening peak expiratory flows from diary cards.
- Spirometry measured at three time points: before, during, and after CPAP therapy.
- Post-CPAP methacholine for bronchial hyperreactivity
|Study Start Date:||December 2004|
|Estimated Study Completion Date:||August 2005|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00238069
|United States, Colorado|
|National Jewish Medical and Research Center|
|Denver, Colorado, United States, 80206|
|Principal Investigator:||Richard Martin, MD||National Jewish Medical and Research Center faculty|