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Genetics of Interstitial Cystitis (magic)

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ClinicalTrials.gov Identifier: NCT00237081
Recruitment Status : Completed
First Posted : October 12, 2005
Last Update Posted : March 17, 2020
Information provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Brief Summary:

The cause of interstitial cystitis is unknown. However, it tends to run in some families suggesting that there may be a genetic susceptibility to the disease. For instance, the disease is found 17 times more commonly in first-degree relatives (parent, sibling, or child) of patients with interstitial cystitis than in the general population. Furthermore, if one twin has interstitial cystitis, the disease is much more common in identical co-twins than fraternal co-twins. This evidence suggests that, in some families, genes that make a person susceptible to interstitial cystitis are being passed from one generation to the next.

The University of Maryland School of Medicine and the National Institutes of Health are performing a study to identify these genes for susceptibility for interstitial cystitis. This study is entitled the Maryland Genetics of Interstitial Cystitis (MaGIC) study. The MaGIC study will investigate several hundred families with two or more blood relatives with interstitial cystitis. The study will seek to find changes in genes that are found far more commonly in family members who have interstitial cystitis than in those who do not have the disease.Identifying these genes should lead to a better understanding of the cause of interstitial cystitis. Finding the cause is the first step to finding the cure.

This is a national study which is conducted by telephone and mail, and in which you can participate entirely from your home.

Condition or disease
Interstitial Cystitis Painful Bladder Syndrome

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Study Type : Observational
Time Perspective: Other
Official Title: Maryland Genetics of Interstitial Cystitis (MaGIC)
Study Start Date : June 2004
Actual Study Completion Date : November 2008

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   13 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Have interstitial cystitis, or painful bladder syndrome.
  • Have at least one blood relative with interstitial cystitis, painful bladder syndrome, or urinary symptoms similar to yours.
  • Are 13 years of age or older.
  • Are available for a telephone, mail, or website interview.
  • Live in the USA or Canada.

Exclusion Criteria:

  • Are less than 13 years of age.
  • Have Parkinson's disease, Multiple Sclerosis, Spina bifida, or another neurologic disease that preceeded your interstitial cystitis symptoms

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00237081

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United States, Maryland
University of Maryland Interstitial Cystitis Center
Baltimore, Maryland, United States, 21201
Sponsors and Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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Principal Investigator: John W Warren, M.D. University of Maryland, College Park
Additional Information:
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ClinicalTrials.gov Identifier: NCT00237081    
Other Study ID Numbers: DK66136-MaGIC (completed)
First Posted: October 12, 2005    Key Record Dates
Last Update Posted: March 17, 2020
Last Verified: March 2010
Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
Interstitial Cystitis
Painful Bladder Syndrome
Risk factors
Family history
Additional relevant MeSH terms:
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Cystitis, Interstitial
Urinary Bladder Diseases
Urologic Diseases