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Genetics of Interstitial Cystitis (magic)

This study has been completed.
Information provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Identifier:
First received: October 11, 2005
Last updated: March 2, 2010
Last verified: March 2010

The cause of interstitial cystitis is unknown. However, it tends to run in some families suggesting that there may be a genetic susceptibility to the disease. For instance, the disease is found 17 times more commonly in first-degree relatives (parent, sibling, or child) of patients with interstitial cystitis than in the general population. Furthermore, if one twin has interstitial cystitis, the disease is much more common in identical co-twins than fraternal co-twins. This evidence suggests that, in some families, genes that make a person susceptible to interstitial cystitis are being passed from one generation to the next.

The University of Maryland School of Medicine and the National Institutes of Health are performing a study to identify these genes for susceptibility for interstitial cystitis. This study is entitled the Maryland Genetics of Interstitial Cystitis (MaGIC) study. The MaGIC study will investigate several hundred families with two or more blood relatives with interstitial cystitis. The study will seek to find changes in genes that are found far more commonly in family members who have interstitial cystitis than in those who do not have the disease.Identifying these genes should lead to a better understanding of the cause of interstitial cystitis. Finding the cause is the first step to finding the cure.

This is a national study which is conducted by telephone and mail, and in which you can participate entirely from your home.

Interstitial Cystitis
Painful Bladder Syndrome

Study Type: Observational
Official Title: Maryland Genetics of Interstitial Cystitis (MaGIC)

Resource links provided by NLM:

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Study Start Date: June 2004
Study Completion Date: November 2008

Ages Eligible for Study:   13 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Have interstitial cystitis, or painful bladder syndrome.
  • Have at least one blood relative with interstitial cystitis, painful bladder syndrome, or urinary symptoms similar to yours.
  • Are 13 years of age or older.
  • Are available for a telephone, mail, or website interview.
  • Live in the USA or Canada.

Exclusion Criteria:

  • Are less than 13 years of age.
  • Have Parkinson's disease, Multiple Sclerosis, Spina bifida, or another neurologic disease that preceeded your interstitial cystitis symptoms
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00237081

United States, Maryland
University of Maryland Interstitial Cystitis Center
Baltimore, Maryland, United States, 21201
Sponsors and Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Principal Investigator: John W Warren, M.D. University of Maryland
  More Information

Additional Information: Identifier: NCT00237081     History of Changes
Other Study ID Numbers: DK66136-MaGIC (completed)
Study First Received: October 11, 2005
Last Updated: March 2, 2010

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
Interstitial Cystitis
Painful Bladder Syndrome
Risk factors
Family history

Additional relevant MeSH terms:
Cystitis, Interstitial
Urinary Bladder Diseases
Urologic Diseases processed this record on May 25, 2017