PET and MRI in the Follow-up of Neoadjuvant Chemotherapy of Breast Cancer
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Predict and follow thanks to imaging the response to neoadjuvant chemotherapy in locally advanced breast carcinoma. Hypothesis : FLT-(18F)PET will be a predictor superior to both FDG-(18F) PET and MRI
Condition or disease
PET/CT with FDG-(18F) and FLT-(18F) and MRI are performed at the initial staging, 3 times during sequential adjuvant chemotherapy and prior to surgery, aiming to find the most efficient modality to predict the response to neoadjuvant chemotherapy of the primary breast cancer and its possible lymph node metastases. Post-surgical histology and a 6 month follow-up (to detect occult metastases) will constitute the standard of truth for determination and comparison of diagnostic performances.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Breast cancer scheduled for neoadjuvant chemotherapy followed by surgery
Indicated chemotherapy without that a curative tumorectomies is foreseen(planned)
Patient presenting an evolutionary infectious or inflammatory pathology, including an inflammatory breast cancer, being able to be source(spring) of false-positive results(profits) in TEP-FDG
Patient in the course of radiotherapy or of chemotherapy or operated at the level of the thorax in 4 weeks preceding the date foreseen(planned) by the examination TEP (pose(installation) of implantable room(chamber) excludes)
Patient already includes in the other protocols of search(research) for Nuclear Medicine or for imaging using ionization radiations
Patient not having given her lit(enlightened) assent
Wait among which the surveillance TEP or the MRI during the chemotherapy will be impossible (that is by geographical or professional imperative, or if contraindication in the MRI, ex: port(bearing) of a pacemaker, cochlear magnetic implants, metal foreign bodies cf protocol)
Of less than 18 years old or pregnant patient.
Breast cancer stage(stadium) IV
Biopsy on the already realized mammary tumor, for the period(delay) lower than 15 j.
In case of alcoholic poisoning or of antecedents of reaction to the injection of ethanol: not inclusion to be discussed.