Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
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ClinicalTrials.gov Identifier: NCT00235586 |
Recruitment Status :
Completed
First Posted : October 10, 2005
Last Update Posted : September 20, 2007
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Postmenopausal Women | Procedure: 10 vit. D deficient subjects take vit. D for 3 months. | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 40 participants |
Allocation: | Non-Randomized |
Intervention Model: | Factorial Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Vitamin D Deficiency: Bone Loss and Vascular Dysfunction |
Study Start Date : | April 2004 |
Actual Study Completion Date : | September 2007 |

- to determine if differences exist in vascular compliance and carotid artery intima media thickness between individuals with normal and low vitamin D levels
- to evaluate correlation of markers of vascular disease and boen disease between individuals with normal and low vitamin D
- to quantify the effect of Vitamin D replacement on vascular compliance and markers of bone loss and vascular disease.
- Vitamin D at the end of 3 months of supplementation.

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Ages Eligible for Study: | 50 Years to 90 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Females ages 50-70 with ability to give informed consent
- One year past last menstrual period
- 20 women with Vitamin D levels < 15 mg/ml
- 20 women with Vitamin D levels > 30 mg/ml
Exclusion Criteria:
- women receiving hormone replacement therapy
- women receiving medication known to effect vascular compliance, including anti-hypertension medications
- subjects receiving therapy for osteoporosis
- hyperthyroidism
- untreated hypothyroidism
- history of metabolic bone disease
- current or previous use of medications known to accelerate bone loss
- chronic liver disease
- chronic renal disease
- diabetes mellitus
- obesity, BMI > 24

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00235586
United States, Kansas | |
University of Kansas Medical Center | |
Kansas City, Kansas, United States, 66160 |
Principal Investigator: | Leland Graves, III, MD | University of Kansas Medical Center |
ClinicalTrials.gov Identifier: | NCT00235586 |
Other Study ID Numbers: |
9248 |
First Posted: | October 10, 2005 Key Record Dates |
Last Update Posted: | September 20, 2007 |
Last Verified: | September 2007 |
vitamin D deficiency postmenopausal women |
Vitamin D Deficiency Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders |