Case Notes Review on Patients With Hereditary Haemorrhagic Telangiectasia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00230685
Recruitment Status : Unknown
Verified August 2008 by Imperial College London.
Recruitment status was:  Recruiting
First Posted : October 3, 2005
Last Update Posted : May 29, 2015
The Margaret Hayton HHT Fund
Information provided by (Responsible Party):
Imperial College London

Brief Summary:
The Hammersmith Hospital provides a clinical service for patients with Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations that is unique in the United Kingdom. Measurements obtained as part of standard clinical practice that has evolved since 1985 allow us to assess whether particular groups of individuals that we see are more prone to recognised complications such as strokes, brain abscesses, pregnancy related complications or pulmonary hypertension. We hypothesise that certain clinical characteristics will predict the susceptibility of individuals to particular complications.

Condition or disease
Telangiectasia, Hereditary Hemorrhagic

Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Hammersmith Hospital Patients With Pulmonary Arteriovenous Malformations (PAVMs) and Hereditary Haemorrhagic Telangiectasia
Study Start Date : January 2000
Estimated Primary Completion Date : January 2018
Estimated Study Completion Date : January 2018

Primary Outcome Measures :
  1. Stroke [ Time Frame: Prospective ]
  2. Venous thromboemboli (VTE) [ Time Frame: Prospective ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients referred to the hereditary haemorrhagic telangiectasia clinical service at Hammersmith Hospital, imperial College Healthcare NHS Trust

Inclusion Criteria:

  • Patients attending Hammersmith Hospital

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00230685

Contact: Claire L Shovlin 0208 383 1000

United Kingdom
Respiratory Medicine, Hammersmith Hospital Recruiting
London, United Kingdom, W12 0NN
Contact: Claire L Shovlin   
Principal Investigator: Claire L Shovlin         
Sponsors and Collaborators
Imperial College London
The Margaret Hayton HHT Fund
Principal Investigator: Claire L Shovlin Imperial College London

Publications of Results:

Responsible Party: Imperial College London Identifier: NCT00230685     History of Changes
Other Study ID Numbers: IC/CLS2
First Posted: October 3, 2005    Key Record Dates
Last Update Posted: May 29, 2015
Last Verified: August 2008

Keywords provided by Imperial College London:
Pulmonary arteriovenous malformations

Additional relevant MeSH terms:
Arteriovenous Malformations
Arteriovenous Fistula
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities
Telangiectasia, Hereditary Hemorrhagic
Vascular Diseases
Cardiovascular Diseases
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases
Vascular Fistula
Pathological Conditions, Anatomical