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Investigation of Plasma Proteins in Patients With Hereditary Haemorrhagic Telangiectasia and PAVMs

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ClinicalTrials.gov Identifier: NCT00230672
Recruitment Status : Unknown
Verified August 2008 by Imperial College London.
Recruitment status was:  Recruiting
First Posted : October 3, 2005
Last Update Posted : August 13, 2008
Sponsor:
Information provided by:
Imperial College London

Study Description
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Brief Summary:
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels, including arteriovenous malformations in the lungs (PAVMs). We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of several proteins in the blood stream. We propose to take blood samples from patients at defined times in order to study changes in blood protein levels and activity

Condition or disease
Telangiectasia, Hereditary Hemorrhagic

Study Design
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Study Type : Observational
Estimated Enrollment : 70 participants
Time Perspective: Prospective
Official Title: Studies of Plasma Proteins Derived From Pulmonary Arteriovenous Malformation Patients
Study Start Date : March 2005

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Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:Patients with hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations -

Exclusion Criteria:Unable to provide informed consent

Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00230672


Contacts
Contact: Claire Shovlin 0208 383 1000 c.shovlin@imperial.ac.uk

Locations
United Kingdom
Imperial College Hammersmith Campus Recruiting
London, United Kingdom, W12 0NN
Contact: Claire Shovlin    0208 383 1000    c.shovlin@imperial.ac.uk   
Sponsors and Collaborators
Imperial College London
Investigators
Principal Investigator: Claire Shovlin Imperial College London
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

ClinicalTrials.gov Identifier: NCT00230672     History of Changes
Other Study ID Numbers: IC/CLS7
First Posted: October 3, 2005    Key Record Dates
Last Update Posted: August 13, 2008
Last Verified: August 2008

Additional relevant MeSH terms:
Arteriovenous Malformations
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities
Telangiectasis
Telangiectasia, Hereditary Hemorrhagic
 Vascular Diseases
Cardiovascular Diseases
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases