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Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia

This study has been completed.
Hammersmith Hospitals NHS Trust
Information provided by (Responsible Party):
Imperial College London Identifier:
First received: September 29, 2005
Last updated: May 28, 2015
Last verified: September 2005

The inherited disease hereditary haemorrhagic telangiectasia (HHT) causes bleeding from dilated fragile vessels, particularly in the nose and gut. However, many HHT patients develop deep venous thromboses and/or pulmonary embolism, necessitating treatments with anticoagulants that further impair control of their haemorrhagic state. Our initial observations using general coagulation tests suggest that the blood of HHT patients is intrinsically hypercoagulable.

We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of one or several of the proteins which affect blood clotting leading to a hypercoagulable state.

We propose to study levels and activity of blood coagulation factors in people with hereditary haemorrhagic telangiectasia and in normal volunteers. This should define the significance and basis for our initial observations, and will have significant implications for the clinical management of HHT patients.

Condition Intervention Phase
Telangiectasia, Hereditary Hemorrhagic
Other: Blood sample to be taken.
Phase 4

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Investigation of Coagulation Parameters in Hereditary Haemorrhagic

Resource links provided by NLM:

Further study details as provided by Imperial College London:

Estimated Enrollment: 100
Study Start Date: August 2004
Study Completion Date: July 2008
Primary Completion Date: July 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
HHT patients
Patients with hereditary haemorrhagic telangiectasia. Blood sample to be taken.
Other: Blood sample to be taken.
Blood sample to be taken.
People without hereditary haemorrhagic telangiectasia. Blood sample to be taken.
Other: Blood sample to be taken.
Blood sample to be taken.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients with HHT and normal controls

Exclusion Criteria:

  • Previous thrombosis, recent ill health
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Please refer to this study by its identifier: NCT00230659

United Kingdom
Imperial College Hammersmith Campus
London, United Kingdom, W12 0NN
Sponsors and Collaborators
Imperial College London
Hammersmith Hospitals NHS Trust
Principal Investigator: Claire Shovlin Imperial College London
  More Information

Responsible Party: Imperial College London Identifier: NCT00230659     History of Changes
Other Study ID Numbers: IC/CLS6
Study First Received: September 29, 2005
Last Updated: May 28, 2015

Additional relevant MeSH terms:
Telangiectasia, Hereditary Hemorrhagic
Vascular Diseases
Cardiovascular Diseases
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities processed this record on April 25, 2017