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Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia

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ClinicalTrials.gov Identifier: NCT00230659
Recruitment Status : Completed
First Posted : October 3, 2005
Last Update Posted : May 29, 2015
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:

The inherited disease hereditary haemorrhagic telangiectasia (HHT) causes bleeding from dilated fragile vessels, particularly in the nose and gut. However, many HHT patients develop deep venous thromboses and/or pulmonary embolism, necessitating treatments with anticoagulants that further impair control of their haemorrhagic state. Our initial observations using general coagulation tests suggest that the blood of HHT patients is intrinsically hypercoagulable.

We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of one or several of the proteins which affect blood clotting leading to a hypercoagulable state.

We propose to study levels and activity of blood coagulation factors in people with hereditary haemorrhagic telangiectasia and in normal volunteers. This should define the significance and basis for our initial observations, and will have significant implications for the clinical management of HHT patients.


Condition or disease Intervention/treatment Phase
Telangiectasia, Hereditary Hemorrhagic Other: Blood sample to be taken. Phase 4

Study Design

Study Type : Observational
Estimated Enrollment : 100 participants
Time Perspective: Prospective
Official Title: Investigation of Coagulation Parameters in Hereditary Haemorrhagic
Study Start Date : August 2004
Primary Completion Date : July 2007
Study Completion Date : July 2008


Groups and Cohorts

Group/Cohort Intervention/treatment
HHT patients
Patients with hereditary haemorrhagic telangiectasia. Blood sample to be taken.
Other: Blood sample to be taken.
Blood sample to be taken.
Controls
People without hereditary haemorrhagic telangiectasia. Blood sample to be taken.
Other: Blood sample to be taken.
Blood sample to be taken.


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients with HHT and normal controls

Exclusion Criteria:

  • Previous thrombosis, recent ill health
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00230659


Locations
United Kingdom
Imperial College Hammersmith Campus
London, United Kingdom, W12 0NN
Sponsors and Collaborators
Imperial College London
Hammersmith Hospitals NHS Trust
Investigators
Principal Investigator: Claire Shovlin Imperial College London
More Information

Publications:
Responsible Party: Imperial College London
ClinicalTrials.gov Identifier: NCT00230659     History of Changes
Other Study ID Numbers: IC/CLS6
First Posted: October 3, 2005    Key Record Dates
Last Update Posted: May 29, 2015
Last Verified: September 2005

Additional relevant MeSH terms:
Telangiectasis
Telangiectasia, Hereditary Hemorrhagic
Vascular Diseases
Cardiovascular Diseases
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities