Dose-Ranging Study of Pradefovir in Patients With Compensated Hepatitis B
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Ages Eligible for Study:
18 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Compensated chronic HBV Infection
No prior treatment with adefovir dipivoxil
No interferon or lamivudine treatment for three months prior to enrollment
HBeAg positive or negative
HBV DNA viral load greater than 500,000 copies per mL
ALT between 1.2 and 10 times ULN
Positive HIV, HCV, and/or HDV serology
History of renal tubular necrosis
Serum creatinine greater than 2.0 mg/dl
History of organ transplant or use of immunosuppresive drugs