Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study) (HSP)
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ClinicalTrials.gov Identifier: NCT00230412 |
Recruitment Status
: Unknown
Verified January 2010 by University of Munich Children's Clinic.
Recruitment status was: Recruiting
First Posted
: September 30, 2005
Last Update Posted
: February 2, 2010
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Condition or disease |
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Kidney Failure, Acute |
A prognostic factor for the development of acute renal failure (ANR) in children would be very valuable for therapy regulation. So-called chaperones out of the family of heat shock proteins (HSP) are promising candidates which are involved in the development of ANR as well. This could be a starting point for the development of new therapeutic approaches.
ANR occurs in up to 50 percent of all critical ill patients and has a high rate of morbidity and mortality despite advances in symptomatic therapy. Following severe sepsis, septic shock or other shocks, combined with multiple organ failure, the ANR is an autonomous prognosis worsening factor.
Should the results of our study show a correlation between the production of HSP and the outcome of children with ANR, further studies would be required, to examine the pathophysiological relevance of HSP in ANR. We would then be able to determine a high risk population for ANR. A modulation of ANR therapy might be a result of further studies.
Study Type : | Observational |
Estimated Enrollment : | 120 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Official Title: | Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study) |
Study Start Date : | October 2005 |
Estimated Study Completion Date : | December 2010 |

- Acute renal failure. [ Time Frame: 28 days ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | up to 18 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Between 0 and 18 years of age.
- Either severe sepsis, shock of any origin or asphyxia.
- Operated patients with operative or post-operative transfusion requirement of at least 0.5 x 80 ml/kg body weight of erythrocyte concentrate.
Exclusion Criteria:
- Existing affection of the kidney.
- Kidney transplantation.
- Missing written consent of the parents or guardian (if applicable).

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00230412
Contact: Dennis A. Ballwieser, cand. med. | +49-89-2621-7564 | dennis.ballwieser@med.uni-muenchen.de | |
Contact: Judith Glöckner-Pagel, Dr. med. | +49-89-5160-2811 | judith.gloeckner@med.uni-muenchen.de |
Germany | |
Klinikum Augsburg, II. Klinik für Kinder und Jugendliche | Recruiting |
Augsburg, Bavaria, Germany, 86156 | |
Contact: Gernot Buheitel, Prof. Dr. +49-821-400-3431 sekretariat@2.kk.augsburg-med.de | |
Contact: Wilfried Schenk, Dr. med. +49-821-400-3431 sekretariat@2.kk.augsburg-med.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Kinderklinik Memmingen | Recruiting |
Memmingen, Bavaria, Germany, 87700 | |
Contact: Martin Ries, Prof. Dr. +49-8331-70-2300 info@kinderklinik-memmingen.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Sub-Investigator: Benjamin Ackermann, cand. med. | |
Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital | Recruiting |
Munich, Bavaria, Germany, 80337 | |
Contact: Dennis A. Ballwieser, cand. med. +49-89-5160-7813 dennis.ballwieser@med.uni-muenchen.de | |
Contact: Judith Glöckner-Pagel, Dr. med. +49-89-5160-7895 judith.gloeckner@med.uni-muenchen.de | |
Principal Investigator: Dennis A. Ballwieser, cand. med. | |
Principal Investigator: Judith Glöckner, Dr. med. | |
Principal Investigator: Karl Reiter, Dr. med. | |
Deutsches Herzzentrum München | Not yet recruiting |
Munich, Bavaria, Germany, 80636 | |
Contact: Gunter Balling, M. D. +49-89-1218 ext 3303 balling@dhm.mhn.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Klinkum der Barmherzigen Brüder St. Hedwig | Recruiting |
Regensburg, Bavaria, Germany, 93049 | |
Contact: Hugo Segerer, Prof. Dr. +49-941-369-5401 kinderundjugendmedizin@barmherzige-regensburg.de | |
Contact: Peter Schindler, Physician +49-941-369-5401 kinderundjugendmedizin@barmherzige-regensburg.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Kinderklinik Rosenheim | Recruiting |
Rosenheim, Bavaria, Germany, 83022 | |
Contact: Torsten Uhlig, Dr. med. +49-8031-3634-51 kinderklinik@kliro.de | |
Contact: Wolfgang John, Dr. med. +49-8031-3634-51 kinderklinik@kliro.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. |
Study Chair: | Karl Reiter, Dr. med. | Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital | |
Study Director: | Judith Glöckner-Pagel, Dr. med. | Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital | |
Principal Investigator: | Dennis A. Ballwieser, cand. med. | Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital |
Additional Information:
Publications:
Responsible Party: | Dennis Ballwieser, LMU Munich |
ClinicalTrials.gov Identifier: | NCT00230412 History of Changes |
Other Study ID Numbers: |
HSP-233-05 Projektnummer 233-05 |
First Posted: | September 30, 2005 Key Record Dates |
Last Update Posted: | February 2, 2010 |
Last Verified: | January 2010 |
Keywords provided by University of Munich Children's Clinic:
Kidney Failure, Acute Acute Renal Failure Kidney Failure Heat-Shock Proteins Children |
Additional relevant MeSH terms:
Renal Insufficiency Acute Kidney Injury Kidney Diseases Urologic Diseases |