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Evaluation of Functional MRI and DTI (Imaging Techniques) in Children With Epilepsy and Focal Brain Lesions

This study has been completed.
Information provided by:
Children's Healthcare of Atlanta Identifier:
First received: September 13, 2005
Last updated: June 24, 2011
Last verified: June 2011
This study is being done to look at the relationship between brain structure and brain function in patients with epilepsy or focal brain lesions (abnormal areas) that require surgery. This study will look at an imaging technique called magnetic resonance imaging (MRI) for looking at the brain. Specifically, the study will look at functional MRI, which is an imaging technique that can map brain function by taking pictures of the brain as it performs different tasks such as reading, thinking, or moving a body part and diffusion tensor imaging (DTI), which will look at brain structure. These types of imaging may help us learn more about different areas of the brain and how those areas of the brain are used in children with epilepsy. We plan to study 30 children with epilepsy.

Condition Intervention
Epilepsy Procedure: Functional MRI, Diffusion Tensor Imaging

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Advanced MR Imaging Evaluation Of Neurosurgical Candidates With Focal Abnormalities

Resource links provided by NLM:

Further study details as provided by Children's Healthcare of Atlanta:

Enrollment: 30
Study Start Date: February 2006
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   4 Years to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • children with intractable epilepsy

Exclusion Criteria:

  • children requiring sedation for scanning
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00229840

United States, Georgia
Children's Healthcare of Atlanta at Scottish Rite
Atlanta, Georgia, United States, 30342
Sponsors and Collaborators
Children's Healthcare of Atlanta
Principal Investigator: Richard Jones, PhD Emory University/Children's Healthcare of Atlanta
  More Information

Responsible Party: Richard Jones, PhD, Children's Healthcare of Atlanta Identifier: NCT00229840     History of Changes
Other Study ID Numbers: Functional MRI
Study First Received: September 13, 2005
Last Updated: June 24, 2011

Keywords provided by Children's Healthcare of Atlanta:
MRI, fMRI, Epilepsy, Pediatric

Additional relevant MeSH terms:
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases processed this record on July 24, 2017