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Study of Medication and Placebo Response in Major Depression

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ClinicalTrials.gov Identifier: NCT00229476
Recruitment Status : Completed
First Posted : September 29, 2005
Last Update Posted : November 7, 2016
Information provided by:

Study Description
Brief Summary:
The primary purpose of the research study is to use recordings of brain electrical activity (through electroencephalogram, or EEG) and symptom measurements to determine whether patients are likely to show a response to medication or placebo treatment during a treatment trial for depression.

Condition or disease Intervention/treatment Phase
Depressive Disorder, Major Drug: sertraline (Zoloft) Phase 4

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : December 2003
Primary Completion Date : March 2006

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Outcome Measures

Primary Outcome Measures :
  1. depressive symptoms

Secondary Outcome Measures :
  1. brain electrical activity (EEG)

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical Diagnosis of Unipolar Major Depression

Exclusion Criteria:

  • Substance Abuse, Psychotic Disorder, History of Severe Head Trauma
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00229476

United States, California
UCLA Neuropsychiatric Institute & Hospital
Los Angeles, California, United States, 90024
Sponsors and Collaborators
University of California, Los Angeles
Eli Lilly and Company
Massachusetts General Hospital
Principal Investigator: Andrew F. Leuchter, M.D. University of California, Los Angeles
More Information

ClinicalTrials.gov Identifier: NCT00229476     History of Changes
Other Study ID Numbers: 03-08-033
First Posted: September 29, 2005    Key Record Dates
Last Update Posted: November 7, 2016
Last Verified: November 2016

Keywords provided by University of California, Los Angeles:

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Mood Disorders
Mental Disorders
Behavioral Symptoms
Antidepressive Agents
Psychotropic Drugs
Serotonin Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Serotonin Agents
Physiological Effects of Drugs