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Study of Genetic Differences in People With Depression (Genetics)

This study has been completed.
Information provided by (Responsible Party):
Andrew F. Leuchter, University of California, Los Angeles Identifier:
First received: September 28, 2005
Last updated: November 16, 2016
Last verified: October 2016
The purpose of this study is to identify genes involved in depression. Specifically, the investigators will analyze some genes that may be related to whether or not a person responds to antidepressant medication. This project is part of basic scientific research to increase understanding of the role of genetic influences in psychological and mental processes involved in the response to treatment for depression.

Depressive Disorder, Major

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Study of Genetic Differences in People With Depression

Further study details as provided by University of California, Los Angeles:

Estimated Enrollment: 200
Study Start Date: January 2002
Study Completion Date: January 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients will be recruited from previous studies conducted at the Laboratory of Brain, Behavior, and Pharmacology, where subjects' response to treatment has already been determined. This strategy offers the advantage that no new subjects need to be enrolled in placebo-controlled treatment studies.

Inclusion Criteria:

  • History of Unipolar Major Depression
  • Control subjects must be healthy normal adults

Exclusion Criteria:

  • Subjects with mood symptoms that are not severe enough to qualify for MDD
  • Subjects with any active medical illness that may be related to ongoing mood disorder
  • Normal subjects must be free from: a psychiatric diagnosis, substance abuse, a history of seizure disorder, and any serious medical illness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00229463

United States, California
UCLA Semel Institute for Neuroscience and Human Behavior
Los Angeles, California, United States, 90024
Sponsors and Collaborators
University of California, Los Angeles
Principal Investigator: Andrew F. Leuchter, M.D. University of California, Los Angeles
  More Information

Responsible Party: Andrew F. Leuchter, Principal Investigator, University of California, Los Angeles Identifier: NCT00229463     History of Changes
Other Study ID Numbers: 01-10-049
Study First Received: September 28, 2005
Last Updated: November 16, 2016

Keywords provided by University of California, Los Angeles:

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders processed this record on April 26, 2017