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Study of Genetic Differences in People With Depression (Genetics)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00229463
First Posted: September 29, 2005
Last Update Posted: November 18, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Andrew F. Leuchter, University of California, Los Angeles
  Purpose
The purpose of this study is to identify genes involved in depression. Specifically, the investigators will analyze some genes that may be related to whether or not a person responds to antidepressant medication. This project is part of basic scientific research to increase understanding of the role of genetic influences in psychological and mental processes involved in the response to treatment for depression.

Condition
Depressive Disorder, Major

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Study of Genetic Differences in People With Depression

Further study details as provided by Andrew F. Leuchter, University of California, Los Angeles:

Estimated Enrollment: 200
Study Start Date: January 2002
Study Completion Date: January 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients will be recruited from previous studies conducted at the Laboratory of Brain, Behavior, and Pharmacology, where subjects' response to treatment has already been determined. This strategy offers the advantage that no new subjects need to be enrolled in placebo-controlled treatment studies.
Criteria

Inclusion Criteria:

  • History of Unipolar Major Depression
  • Control subjects must be healthy normal adults

Exclusion Criteria:

  • Subjects with mood symptoms that are not severe enough to qualify for MDD
  • Subjects with any active medical illness that may be related to ongoing mood disorder
  • Normal subjects must be free from: a psychiatric diagnosis, substance abuse, a history of seizure disorder, and any serious medical illness
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00229463


Locations
United States, California
UCLA Semel Institute for Neuroscience and Human Behavior
Los Angeles, California, United States, 90024
Sponsors and Collaborators
University of California, Los Angeles
Investigators
Principal Investigator: Andrew F. Leuchter, M.D. University of California, Los Angeles
  More Information

Responsible Party: Andrew F. Leuchter, Principal Investigator, University of California, Los Angeles
ClinicalTrials.gov Identifier: NCT00229463     History of Changes
Other Study ID Numbers: 01-10-049
First Submitted: September 28, 2005
First Posted: September 29, 2005
Last Update Posted: November 18, 2016
Last Verified: October 2016

Keywords provided by Andrew F. Leuchter, University of California, Los Angeles:
Depression
genetic
gene
antidepressant
research

Additional relevant MeSH terms:
Depression
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders