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Treatment With Ziprasidone for Schizophrenia Patients With Obsessive Compulsive Disorder (OCD)

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ClinicalTrials.gov Identifier: NCT00229385
Recruitment Status : Completed
First Posted : September 29, 2005
Last Update Posted : December 31, 2013
Sponsor:
Information provided by (Responsible Party):
Prof. Joseph Zohar, Sheba Medical Center

Brief Summary:
Comparing schizophrenic patients with comorbid OCD and schizophrenic patients without OCD in response to Ziprasidone and in cognitive functioning as compared with OCD patients

Condition or disease Intervention/treatment
Schizophrenia Obsessive Compulsive Disorder Drug: Ziprasidone

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 45 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Treatment With Ziprasidone for Schizophrenia Patients With Obsessive Compulsive Disorder (OCD)
Study Start Date : January 2006
Primary Completion Date : April 2008
Study Completion Date : April 2010


Arm Intervention/treatment
Active Comparator: 1 Drug: Ziprasidone
40-80 mg BID
Active Comparator: 2 Drug: Ziprasidone
40-80 mg BID



Primary Outcome Measures :
  1. YBOCS [ Time Frame: 8 weeks ]


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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosis of Schizophrenia and OCD for at least 6 months
  • Minimum score of 14 on YBOCS
  • Minimum score of 60 on PANSS
  • Diagnosis of Schizophrenia without OC symptoms

Exclusion Criteria:

  • Patients who are already being treated with ziprasidone
  • Diagnosis of schizophreniform disorder
  • Organic brain syndrome, mental retardation and pervasive developmental disorder
  • Patients having any significantly cardiovascular illness or electrolyte imbalance

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00229385


Locations
Israel
Chaim Sheba Medical Center
Ramat-Gan, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center
Investigators
Principal Investigator: Joseph Zohar, MD Tel Aviv University

Responsible Party: Prof. Joseph Zohar, Sheba Medical Center
ClinicalTrials.gov Identifier: NCT00229385     History of Changes
Other Study ID Numbers: SHEBA-03-3061-JS-CTIL
First Posted: September 29, 2005    Key Record Dates
Last Update Posted: December 31, 2013
Last Verified: December 2013

Additional relevant MeSH terms:
Disease
Schizophrenia
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Pathologic Processes
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Personality Disorders
Anxiety Disorders
Ziprasidone
Serotonin Antagonists
Serotonin Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
Dopamine Antagonists
Dopamine Agents