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Ischemia and Reperfusion Injury in the Human: An Observational Study

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2008 by Lawson Health Research Institute.
Recruitment status was:  Recruiting
Sponsor:
Information provided by:
Lawson Health Research Institute
ClinicalTrials.gov Identifier:
NCT00229047
First received: September 27, 2005
Last updated: December 18, 2008
Last verified: December 2008
  Purpose
We, the researchers at Lawson Health Research Institute, propose to investigate the impact of surgical ischemia and reperfusion on skeletal muscle microcirculation using a hand-held microscope.

Condition
Ischemia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Ischemia and Reperfusion Injury in the Human: An Observational Study

Further study details as provided by Lawson Health Research Institute:

Estimated Enrollment: 20
Study Start Date: April 2005
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
Vein Stripping
Patients undergoing elective varicose vein stripping in our vascular OR. Observe circulation in the exposed soleus/gastrocnemius muscle.

Detailed Description:
We propose to investigate the impact of surgical ischemia and reperfusion on skeletal muscle microcirculation using a hand-held microscope.
  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing routine and elective varicose vein stripping.
Criteria

Inclusion Criteria:

  • Patients undergoing femoral distal bypass procedures for chronic limb ischemia

Exclusion Criteria:

  • Any severe comorbid conditions (i.e., chronic obstructive pulmonary disease [COPD])
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00229047

Contacts
Contact: Amit Badhwar, PhD 519.685.8500 amit.badhwar@uwo.ca
Contact: Marge Lovell, RN 519.685.8500 marg.lovell@lhsc.on.ca

Locations
Canada, Ontario
Lawson Health Research Institute Recruiting
London, Ontario, Canada, N6A 4G5
Contact: Amit Badhwar, PhD    519.685.8500    amit.badhwar@uwo.ca   
Sub-Investigator: Amit Badhwar, PhD         
Sponsors and Collaborators
Lawson Health Research Institute
Investigators
Study Director: Amit Badhwar, PhD Scientist
Principal Investigator: Tom Forbes, MD Vascular Surgeon
  More Information

Responsible Party: Dr. T. Forbes, Lawson Health Research Institute
ClinicalTrials.gov Identifier: NCT00229047     History of Changes
Other Study ID Numbers: R-05-133
11268E
Study First Received: September 27, 2005
Last Updated: December 18, 2008

Keywords provided by Lawson Health Research Institute:
Ischemic Preconditioning
Microvascular Perfusion
Inflammation
Ischemia and Reperfusion
Chronic Limb Ischemia

Additional relevant MeSH terms:
Ischemia
Reperfusion Injury
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications

ClinicalTrials.gov processed this record on May 25, 2017