We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Ischemia and Reperfusion Injury in the Human: An Observational Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00229047
Recruitment Status : Completed
First Posted : September 29, 2005
Last Update Posted : August 25, 2017
Sponsor:
Information provided by:

Study Description
Brief Summary:
We, the researchers at Lawson Health Research Institute, propose to investigate the impact of surgical ischemia and reperfusion on skeletal muscle microcirculation using a hand-held microscope.

Condition or disease
Ischemia

Detailed Description:
We propose to investigate the impact of surgical ischemia and reperfusion on skeletal muscle microcirculation using a hand-held microscope.

Study Design

Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Ischemia and Reperfusion Injury in the Human: An Observational Study
Actual Study Start Date : April 2005
Primary Completion Date : December 2010
Study Completion Date : December 2011
Groups and Cohorts

Group/Cohort
Vein Stripping
Patients undergoing elective varicose vein stripping in our vascular OR. Observe circulation in the exposed soleus/gastrocnemius muscle.


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing routine and elective varicose vein stripping.
Criteria

Inclusion Criteria:

  • Patients undergoing femoral distal bypass procedures for chronic limb ischemia

Exclusion Criteria:

  • Any severe comorbid conditions (i.e., chronic obstructive pulmonary disease [COPD])
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00229047


Locations
Canada, Ontario
Lawson Health Research Institute
London, Ontario, Canada, N6A 4G5
Sponsors and Collaborators
Lawson Health Research Institute
Investigators
Study Director: Amit Badhwar, PhD Scientist
Principal Investigator: Tom Forbes, MD Vascular Surgeon
More Information

Responsible Party: Dr. T. Forbes, Lawson Health Research Institute
ClinicalTrials.gov Identifier: NCT00229047     History of Changes
Other Study ID Numbers: R-05-133
11268E
First Posted: September 29, 2005    Key Record Dates
Last Update Posted: August 25, 2017
Last Verified: August 2017

Keywords provided by Lawson Health Research Institute:
Ischemic Preconditioning
Microvascular Perfusion
Inflammation
Ischemia and Reperfusion
Chronic Limb Ischemia

Additional relevant MeSH terms:
Ischemia
Reperfusion Injury
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications