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Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione

This study has been completed.
National Institutes of Health (NIH)
Information provided by:
Emory University Identifier:
First received: September 27, 2005
Last updated: January 29, 2009
Last verified: January 2009
Availability of sulfur amino acids (SAA) is critical for glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (CYS/CYSS) redox in vivo and for many other physiologic functions including protein synthesis, nitrogen balance, digestion, osmotic regulation, detoxification, hormonal regulation, biologic methylations, and cell growth regulation. GSH conjugation and sulfate conjugation represent quantitatively important pathways for chemical detoxification, which imposes substantial burden upon SAA supply. The primary hypothesis is that SAA deficient diet and acetaminophen (APAP) administration will perturb Cys metabolism and GSH redox homeostasis in human plasma and urinary output of SAA metabolites. Because both of these variations affect SAA homeostasis, it is believed that the combination of these treatments will produce an interactive effect in which 2-day SAA deficiency will alter APAP metabolism, APAP will affect SAA homeostasis, and the treatments together will alter the global metabolic profile, as measured by 1H-NMR spectroscopy.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione and Cysteine.

Resource links provided by NLM:

Further study details as provided by Emory University:

Estimated Enrollment: 15
Study Start Date: July 2005
Study Completion Date: January 2009
  Show Detailed Description


Ages Eligible for Study:   18 Months to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy volunteers

Inclusion Criteria:


Exclusion Criteria:

smokers greater or less than 10% of ideal body weight illness

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00228644

United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
National Institutes of Health (NIH)
Principal Investigator: Dean P Jones, Ph.D. Emory University
  More Information

Responsible Party: Dean Jones, PhD Professor, Emory University Identifier: NCT00228644     History of Changes
Other Study ID Numbers: 501-2004
Study First Received: September 27, 2005
Last Updated: January 29, 2009

Keywords provided by Emory University:
oxidative stress
amino acids
dietary requirements

Additional relevant MeSH terms:
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Antipyretics processed this record on June 23, 2017