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Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00228644
First Posted: September 29, 2005
Last Update Posted: January 30, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institutes of Health (NIH)
Information provided by:
Emory University
  Purpose
Availability of sulfur amino acids (SAA) is critical for glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (CYS/CYSS) redox in vivo and for many other physiologic functions including protein synthesis, nitrogen balance, digestion, osmotic regulation, detoxification, hormonal regulation, biologic methylations, and cell growth regulation. GSH conjugation and sulfate conjugation represent quantitatively important pathways for chemical detoxification, which imposes substantial burden upon SAA supply. The primary hypothesis is that SAA deficient diet and acetaminophen (APAP) administration will perturb Cys metabolism and GSH redox homeostasis in human plasma and urinary output of SAA metabolites. Because both of these variations affect SAA homeostasis, it is believed that the combination of these treatments will produce an interactive effect in which 2-day SAA deficiency will alter APAP metabolism, APAP will affect SAA homeostasis, and the treatments together will alter the global metabolic profile, as measured by 1H-NMR spectroscopy.

Condition
Healthy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione and Cysteine.

Resource links provided by NLM:


Further study details as provided by Emory University:

Estimated Enrollment: 15
Study Start Date: July 2005
Study Completion Date: January 2009
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Months to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy volunteers
Criteria

Inclusion Criteria:

healthy

Exclusion Criteria:

smokers greater or less than 10% of ideal body weight illness

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00228644


Locations
United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
National Institutes of Health (NIH)
Investigators
Principal Investigator: Dean P Jones, Ph.D. Emory University
  More Information

Responsible Party: Dean Jones, PhD Professor, Emory University
ClinicalTrials.gov Identifier: NCT00228644     History of Changes
Other Study ID Numbers: 501-2004
First Submitted: September 27, 2005
First Posted: September 29, 2005
Last Update Posted: January 30, 2009
Last Verified: January 2009

Keywords provided by Emory University:
oxidative stress
amino acids
acetaminophen
dietary requirements

Additional relevant MeSH terms:
Acetaminophen
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Antipyretics