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Dietary Effects of Sulfur Amino Acids

This study has been completed.
National Institutes of Health (NIH)
Information provided by:
Emory University Identifier:
First received: September 27, 2005
Last updated: January 29, 2009
Last verified: January 2009
The purpose of this study is to determine the level of sulfur amino acids in the diet that is needed to maintaining glutathione antioxidant status. This information could prove very useful in medicine because it could allow identification of an optimal diet for control of antioxidant levels. This diet could be used in conjunction with other therapies in order to prevent or delay oxidative stress and any diseases that may result from this. Total study participation will include a screening visit and a 14-day study period where dietary intake of sulfur amino acids will be controlled. We aim to enroll 12 normal subjects at Emory University Hospital.The primary hypothesis is that steady-state GSH/GSSG and CYS/CYSS redox in human plasma will become oxidized due to SAA intake at 0% of the RDA and reduced due to SAA intake at 3X the RDA.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Dietary Effects of Sulfur Amino Acid Depletion and Repletion on Glutathione and Cysteine Pools.

Resource links provided by NLM:

Further study details as provided by Emory University:

Estimated Enrollment: 20
Study Start Date: January 2005
Study Completion Date: January 2009
  Show Detailed Description


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers

Inclusion Criteria:

  • within 10% of ideal body weight

Exclusion Criteria:

  • smoker
  • illness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00228618

United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
National Institutes of Health (NIH)
Principal Investigator: Dean P Jones Emory University
  More Information

Responsible Party: Dean Jones, PhD Professor, Emory University Identifier: NCT00228618     History of Changes
Other Study ID Numbers: 1098-2003
Study First Received: September 27, 2005
Last Updated: January 29, 2009

Keywords provided by Emory University:
oxidative stress
amino acids
dietary requirements processed this record on June 23, 2017