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Dietary Effects of Sulfur Amino Acids

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00228618
Recruitment Status : Completed
First Posted : September 29, 2005
Last Update Posted : January 30, 2009
National Institutes of Health (NIH)
Information provided by:
Emory University

Brief Summary:
The purpose of this study is to determine the level of sulfur amino acids in the diet that is needed to maintaining glutathione antioxidant status. This information could prove very useful in medicine because it could allow identification of an optimal diet for control of antioxidant levels. This diet could be used in conjunction with other therapies in order to prevent or delay oxidative stress and any diseases that may result from this. Total study participation will include a screening visit and a 14-day study period where dietary intake of sulfur amino acids will be controlled. We aim to enroll 12 normal subjects at Emory University Hospital.The primary hypothesis is that steady-state GSH/GSSG and CYS/CYSS redox in human plasma will become oxidized due to SAA intake at 0% of the RDA and reduced due to SAA intake at 3X the RDA.

Condition or disease

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Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Dietary Effects of Sulfur Amino Acid Depletion and Repletion on Glutathione and Cysteine Pools.
Study Start Date : January 2005
Actual Study Completion Date : January 2009

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers

Inclusion Criteria:

  • within 10% of ideal body weight

Exclusion Criteria:

  • smoker
  • illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00228618

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United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322
Sponsors and Collaborators
Emory University
National Institutes of Health (NIH)
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Principal Investigator: Dean P Jones Emory University

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Responsible Party: Dean Jones, PhD Professor, Emory University Identifier: NCT00228618    
Other Study ID Numbers: 1098-2003
First Posted: September 29, 2005    Key Record Dates
Last Update Posted: January 30, 2009
Last Verified: January 2009
Keywords provided by Emory University:
oxidative stress
amino acids
dietary requirements