Maintenance Interpersonal Psychotherapy for Sustaining Remission of Depression
This study will evaluate the effectiveness of maintenance interpersonal psychotherapy (IPT) in preventing relapse of depression in women who have required combined psychotherapy and pharmacotherapy treatment to obtain a remission of depression symptoms.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Maintenance Psychotherapies in Recurrent Depression: Study II|
- Score on the Hamilton Rating Scale for Depression (measured at Month 24)
- Score on the Beck Depression Inventory
- Score on the Global Assessment of Functioning (measured at Month 24)
|Study Start Date:||March 1995|
|Estimated Study Completion Date:||March 2001|
Depression is a serious medical illness that can recur more than once in a person's lifetime. Effective treatment methods are needed to maintain a state of remission in people who have had prior episodes of depression. IPT is a brief and highly structured type of psychotherapy that addresses interpersonal issues associated with depression. Previous studies have shown that it is an effective method for treating depression. This study will evaluate the effectiveness of maintenance ITP in preventing relapse of depression in women who have required combined psychotherapy and pharmacotherapy treatment to obtain remission of depressive symptoms.
Participants in this open label study will be recruited from a previous study, "Maintenance Psychotherapy in Recurrent Depression: Study I." In this study participants will initially receive weekly sessions of IPT as well as medication treatment with fluoxetine. Any participants who do not reach remission of depressive symptoms after 6 weeks will be given other standard treatments for depression. Once remission of depressive symptoms is reached, participants will continue receiving weekly IPT and fluoxetine treatment for 20 weeks. After 20 weeks, fluoxetine treatment will be discontinued, and all participants will receive IPT alone for 6 weeks before entering the maintenance phase of the study. Upon entrance into this phase, participants will be randomly assigned to receive IPT weekly, biweekly, or monthly for 18 months. Functioning and depressive symptoms will be assessed at Month 24.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00227981
|United States, Pennsylvania|
|Western Psychiatric Institute and Clinic|
|Pittsburgh, Pennsylvania, United States, 15237|
|Principal Investigator:||Ellen Frank, PhD||University of Pittsburgh|