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Genetic Determinants of Opioids Analgesia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00226564
Recruitment Status : Completed
First Posted : September 27, 2005
Last Update Posted : October 29, 2008
Sponsor:
Information provided by:
Hadassah Medical Organization

Brief Summary:

The response to opioids varies greatly among individuals. Some of these variability is accounted for by genetic factors.

The present study was designed to evaluate the possibility that genetic polymorphism in the gene encoding for mu opioid receptor may explain variability in the response to alfentanil during lithotripsy.


Condition or disease Intervention/treatment
Nephrolithiasis Drug: Alfentanil

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Effect of mu Opioid Receptor Polymorphism on the Response to Alfentanil During Lithotripsy
Study Start Date : August 1997

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Stones
U.S. FDA Resources




Primary Outcome Measures :
  1. Total alfentanil dose used during the procedure.
  2. The extent of respiratory depression.


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age > 20

Exclusion Criteria:

  • Regular use of opioid drugs
  • Known hypersensitivity to alfentanil

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00226564


Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Principal Investigator: Yoseph Caraco, MD Hadassah Medical Organization

ClinicalTrials.gov Identifier: NCT00226564     History of Changes
Other Study ID Numbers: yc19554-HMO-CTIL
First Posted: September 27, 2005    Key Record Dates
Last Update Posted: October 29, 2008
Last Verified: October 2008

Additional relevant MeSH terms:
Nephrolithiasis
Kidney Calculi
Kidney Diseases
Urologic Diseases
Urolithiasis
Urinary Calculi
Calculi
Pathological Conditions, Anatomical
Alfentanil
Analgesics, Opioid
Narcotics
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Anesthetics, Intravenous
Anesthetics, General
Anesthetics