The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal
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Purpose
Monosymptomatic nocturnal enuresis, defined as the involuntary loss of urine during the night at an age where voluntary bladder control should have been attained and on the background of normal urinary tract function, is a rather common disease of childhood with an estimated prevalence of 5-10% at tha age of 7 and a spontaneous remission rate of 15% per year.
The present study consists of two phases; an in-patient phase and an ambulatory phase.
In the in-patient phase we will examine the regulation of sodium and the circadian rhythm of the hormones that affect this regulation in children with enuresis nocturnal and healthy children, as well as the impact of indomethacin on renal water and electrolyte excretion.
In the ambulatory phase we will examine the efficacy and safety of a treatment modality consisting of a combination of dDAVP and indomethacin in patients with severe enuresis where dDAVP as monotherapy is inadequate.
A significant number of children with enuresis and nocturnal polyuria do not respond to treatment with dDAVP. If a combination treatment with dDAVP and indomethacin proves superior to dDAVP alone the regimen could readily be used in those difficult to cure cases of enuresis.
| Condition | Intervention | Phase |
|---|---|---|
|
Enuresis |
Drug: Indomethacin |
Phase 4 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Caregiver, Investigator) Primary Purpose: Treatment |
| Official Title: | The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal |
- Enuresis episodes [ Time Frame: 3 and 7 weeks ] [ Designated as safety issue: No ]
- Urine production, electrolyte excretion, hormonal changes [ Time Frame: 3 and 7 weeks ] [ Designated as safety issue: No ]
| Enrollment: | 56 |
| Study Start Date: | January 2003 |
| Study Completion Date: | December 2009 |
| Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
-
Drug: Indomethacin
The "in-patient" phase is a comparative circadian study of three groups of participants and a non-placebo controlled study of the renal effects of indomethacin with special reference the renal handling of sodium.
The ambulatory phase is designed as a randomized double blind, crossover placebo controlled for indomethacin study of the efficacy and safety of a combination treatment with indomethacin and dDAVP.
In-patient phase: Primary effect parameters will be the diuresis, urinary osmolality, sodium excretion prior to and after the administration of indomethacin.
Secondary effect parameters will be the following: GFR, K+ excretion, creatinine excretion, urea excretion, as well as urinary concentrations of aquaporin 2 (AQP2), PGE2, AVP, URO, Na-transporter protein, concentration of renin, ANG II, ALDO, ANP, in plasma, prior to and after the administration of indomethacin.
Ambulatory phase: Primary effect parameter will be the number of dry nights achieved in the two treatment periods. Secondary effect parameters will be the nocturnal urine production, and the enuresis volumes In-patient phase: Day-night ratios will be calculated for all parameters tested. The circadian rhythm of hormones blood pressure and electrolyte excretion will be analyzed using COSINOR analysis.
The effect of indomethacin on the parameters tested will be compared to the basal measurements using student's t-test, ANOVA for repeated measurements or non-parametric tests. All statistical inference will take place on a "protocol population" basis.
Ambulatory phase: The efficacy of the combination treatment will be tested against placebo (only for indomethacin) with help of student's t-test, x2 test or non-parametric tests.
The results from the home recordings will be compared for the two treatment periods using non-parametric tests. The effect parameters that will undergo statistical analysis are the number of wet nights, the enuresis volume and the nocturnal urine production. The analysis will be on the basis of intention to treat population.
Eligibility| Ages Eligible for Study: | 7 Years to 14 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Monosymptomatic enuresis nocturnal
- At least 3 nights with enuresis per week
- Incomplete response to dDAVP
Exclusion Criteria:
- Daytime incontinence
- Urgency
- Frequency
- Other conditions that influence normal urine production
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00226122
| Denmark | |
| Dept of Pediatrics, Aarhus University Hospital | |
| Aarhus N, Jutland, Denmark, 8200 | |
| Principal Investigator: | Konstantinos Kamperis, MD. PhD | Clinical Institute, University of Aarhus |
More Information
No publications provided
| Responsible Party: | Konstantinos Kamperis MD PhD, Pediatric Research Laboratory, Aarhus University Hospital Skejby Aarhus Denmark |
| ClinicalTrials.gov Identifier: | NCT00226122 History of Changes |
| Other Study ID Numbers: | INDO181202, 01 |
| Study First Received: | September 23, 2005 |
| Last Updated: | June 24, 2010 |
| Health Authority: | Denmark: National Board of Health |
Keywords provided by University of Aarhus:
|
Enuresis Nocturnal Monosymptomatic |
DDAVP Indomethacin Randomized |
Additional relevant MeSH terms:
|
Enuresis Nocturnal Enuresis Behavioral Symptoms Elimination Disorders Mental Disorders Mental Disorders Diagnosed in Childhood Urination Disorders Urologic Diseases Indomethacin Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents |
Cardiovascular Agents Central Nervous System Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Gout Suppressants Molecular Mechanisms of Pharmacological Action Peripheral Nervous System Agents Pharmacologic Actions Physiological Effects of Drugs Reproductive Control Agents Sensory System Agents Therapeutic Uses Tocolytic Agents |
ClinicalTrials.gov processed this record on March 03, 2015