Study of Blood Platelets in Sickle Cell Disease

This study has suspended participant recruitment.
(PI returned to India)
Mount Sinai School of Medicine
Schneider Children's Hospital of North Shore
Information provided by:
Rockefeller University Identifier:
First received: September 22, 2005
Last updated: October 15, 2007
Last verified: October 2007

We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.

Sickle Cell Disease

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Studies of Large Platelets in Patients With Sickle Cell Disease

Resource links provided by NLM:

Further study details as provided by Rockefeller University:

Estimated Enrollment: 90
Study Start Date: August 2005
Estimated Study Completion Date: June 2007
Detailed Description:

Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.


Ages Eligible for Study:   7 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Adults and children > 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy.

Exclusion Criteria:

  • Current hydroxyurea therapy or,
  • Hydroxyurea use within the past 3 months
  • Blood transfusion or exchange transfusion within the past 3 months
  • Current treatment with aspirin or clopidogrel
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00226083

United States, New York
Rockefeller University Hospital
New York, New York, United States, 10021
Sponsors and Collaborators
Rockefeller University
Mount Sinai School of Medicine
Schneider Children's Hospital of North Shore
Principal Investigator: Arun Shet, MD Rockefeller University
  More Information

No publications provided Identifier: NCT00226083     History of Changes
Other Study ID Numbers: RUH IRB # AST-0565-0805
Study First Received: September 22, 2005
Last Updated: October 15, 2007
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic
Anemia, Hemolytic, Congenital
Genetic Diseases, Inborn
Hematologic Diseases
Hemoglobinopathies processed this record on May 20, 2015