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Study of Blood Platelets in Sickle Cell Disease

This study has been withdrawn prior to enrollment.
(PI returned to India)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00226083
First Posted: September 26, 2005
Last Update Posted: June 9, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Icahn School of Medicine at Mount Sinai
Schneider Children's Hospital of North Shore
Information provided by (Responsible Party):
Rockefeller University
  Purpose
We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.

Condition
Sickle Cell Disease

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Studies of Large Platelets in Patients With Sickle Cell Disease

Resource links provided by NLM:


Further study details as provided by Rockefeller University:

Enrollment: 0
Study Start Date: August 2005
Estimated Study Completion Date: September 2007
Estimated Primary Completion Date: September 2007 (Final data collection date for primary outcome measure)
Detailed Description:
Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   7 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adults and children with sickle cell disease (Hb SS)
Criteria

Inclusion Criteria:

  • Adults and children > 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy.

Exclusion Criteria:

  • Current hydroxyurea therapy or,
  • Hydroxyurea use within the past 3 months
  • Blood transfusion or exchange transfusion within the past 3 months
  • Current treatment with aspirin or clopidogrel
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00226083


Locations
United States, New York
Rockefeller University Hospital
New York, New York, United States, 10021
Sponsors and Collaborators
Rockefeller University
Icahn School of Medicine at Mount Sinai
Schneider Children's Hospital of North Shore
Investigators
Principal Investigator: Arun Shet, MD Rockefeller University
  More Information

Responsible Party: Rockefeller University
ClinicalTrials.gov Identifier: NCT00226083     History of Changes
Other Study ID Numbers: RUH IRB # AST-0565-0805
First Submitted: September 22, 2005
First Posted: September 26, 2005
Last Update Posted: June 9, 2015
Last Verified: June 2015

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn