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Study of Blood Platelets in Sickle Cell Disease

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ClinicalTrials.gov Identifier: NCT00226083
Recruitment Status : Withdrawn (PI returned to India)
First Posted : September 26, 2005
Last Update Posted : June 9, 2015
Sponsor:
Collaborators:
Icahn School of Medicine at Mount Sinai
Schneider Children's Hospital of North Shore
Information provided by (Responsible Party):
Rockefeller University

Brief Summary:
We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.

Condition or disease
Sickle Cell Disease

Detailed Description:
Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.

Study Type : Observational
Actual Enrollment : 0 participants
Time Perspective: Prospective
Official Title: Studies of Large Platelets in Patients With Sickle Cell Disease
Study Start Date : August 2005
Estimated Primary Completion Date : September 2007
Estimated Study Completion Date : September 2007

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Ages Eligible for Study:   7 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adults and children with sickle cell disease (Hb SS)
Criteria

Inclusion Criteria:

  • Adults and children > 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy.

Exclusion Criteria:

  • Current hydroxyurea therapy or,
  • Hydroxyurea use within the past 3 months
  • Blood transfusion or exchange transfusion within the past 3 months
  • Current treatment with aspirin or clopidogrel

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00226083


Locations
United States, New York
Rockefeller University Hospital
New York, New York, United States, 10021
Sponsors and Collaborators
Rockefeller University
Icahn School of Medicine at Mount Sinai
Schneider Children's Hospital of North Shore
Investigators
Principal Investigator: Arun Shet, MD Rockefeller University

Responsible Party: Rockefeller University
ClinicalTrials.gov Identifier: NCT00226083     History of Changes
Other Study ID Numbers: RUH IRB # AST-0565-0805
First Posted: September 26, 2005    Key Record Dates
Last Update Posted: June 9, 2015
Last Verified: June 2015

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn