Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by Patient-Controlled Analgesia With Morphine
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Ages Eligible for Study:
5 Years to 18 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Child from 5 to 18 years.
Presenting mucitis induced by chemotherapy or a conditioning of graft hematopoïetic.
A pain not controlled by systematic paracetamol (10mg/kg/4h) or a the propacetamol (20mg/kg/4h).
Not presenting a neurological or psychological difficulty at the use of the PCA or a EVA.
First morphine amount going back to less 48h, and lass administration dating of more than 4h at the time of the beginning of the perfusion of Ketamine/placebo (EVA > 30 after stop morphine).
Assent signed by the parents and each time possible by the child.
The child was already included in the study.
The age of psychomotor development is lower than 5 years
Presence of a depression or a major depressive episode according to definition DSM IV.
Hepatic or renal anomaly major (rank 3 or 4 of the scale of toxicity NCI CTC v2.0)