Clozapine-Augmentation With Ziprasidone or Risperidone, a Randomized, Prospective Trial
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We aim to compare the augmentation of clozapine with ziprasidone or risperidone in a randomized, prospective manner.
Condition or disease
Schizophrenia, Schizoaffective Disorder
Drug: ziprasidoneDrug: risperidone
Partial response of schizophrenic psychoses to a monotherapy with clozapine is a frequent problem of clinical psychiatry. Current problems are treatment resistant positive and/or negative symptoms, as well as side effects. Therefore, different strategies of augmentations have been applied. Based on successful experiences in case reports and results of other work groups, we aim to compare the augmentation of clozapine with ziprasidone or risperidone in a randomized, prospective manner.
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Ages Eligible for Study:
18 Years to 70 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Treatment resistant schizophrenic or schizoaffective disorder under therapy with clozapine,
Age between 18 and 70,
No informed consent,
Intolerance with respect to ziprasidone or risperidone,
Contraindications with respect to these substances,