Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy
|Smoking Lung Diseases||Procedure: Bronchopulmonary Lung Lavage Procedure: Bronchial Brushing Procedure: Bronchial Wall Biopsy|
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Evaluation of the Lungs of Normal Individuals With Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing and Bronchial Wall Biopsy|
- Evaluate etiology of lung diseases [ Time Frame: 9/31/2012 ]We hope to learn more about the specific causes of lung disease, how lung disease manifests and progresses, and how lung disease can be treated.
- Effect of smoking on the genes of airway epithelial cells [ Time Frame: 9/31/2012 ]We hope to learn how smoking affects the genetic composition of the cells that line the airways (windpipes) of the lungs, and whether there are differences in the genetic composition of the cells that line the windpipe in normal individuals who smoke.
Biospecimen Retention: Samples With DNA
|Study Start Date:||January 2004|
|Study Completion Date:||September 2012|
|Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
Procedure: Bronchopulmonary Lung Lavage
Study procedures will be performed at the Weill Cornell Medical College-New York Presbyterian Hospital and/or Weill Greenburg York Avenue Building. Study procedures done elsewhere that are within the protocol timeframe will be accepted if seen fit by the investigators so that they are not repeated unnecessarily. Study individuals who undergo bronchoscopy with intravenous administration of sedatives and analgesia may be required to stay overnight. Bronchoscopy is normally an ambulatory procedure. The subject is observed after the bronchoscopy, including vital signs and level of consciousness, until they are back to baseline. An overnight stay would only be required if the individual was not, in the judgment of the attending physician, safe to be discharged as is standard practice. Follow up of all participants are carried out by telephone within 1 wk following the procedure.
Rockefeller University has been added as a second site.
Individuals undergoing bronchoscopy without intravenous administration of sedatives and analgesia are not required to stay overnight due to the lack of administration of CNS-altering drugs and the limited sampling involved (tracheal brushes only).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00224185
|United States, New York|
|Department of Genetic Medicine, WMC of Cornell Univeristy|
|New York, New York, United States, 10021|
|Principal Investigator:||Ronald G Crystal, MD||Department of Genetic Medicine, Weill Cornell Medical College|