The Use of Anabolic Steroids to Improve Function After Spinal Cord Injury
The purpose of this study is to determine the effect of oxandrolone on the function and quality of life of patients with chronic spinal cord injury.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Primary Purpose: Treatment
|Official Title:||The Use of Oxandrolone to Improve Function in Persons With Chronic Spinal Cord Injury|
- Part-A: lean body mass, upper extremity muscle strength. Measures are made at baseline, 12-weeks (end of intervention), and at 24-weeks.
- Part-B: respiratory function, efficency of ambulaton (speed and quality of gait). Measures are made at baseline,
- 12-weeks (end of intervention), and at 24-weeks.
- Part-A: maximum VO2/respiratory function, functional status, safety, quality of life, community
- Part-B: upper extremity strength, lean body mass, functional status, safety, quality of life, community
|Study Start Date:||January 2004|
|Study Completion Date:||May 2006|
Spinal cord injury results in significant loss of muscle mass. Oxandrolone, a derivative of testosterone, is an anabolic steroid shown to promote gain in body weight and muscle mass after trauma, severe illness, surgery, burns, and stress. To date there are no studies that have evaluated the effect of oxandrolone in persons with chronic spinal cord injury. This study will assess the effect of oxandrolone on strength, metabolic rate, lean body mass, pulmonary function, and ambulation in persons with chronic SCI. This study has the potential to yield valuable information concerning the use of oxandrolone after SCI.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00223769
|United States, Florida|
|Miami Veterans Affairs Medical Center|
|Miami, Florida, United States, 33125|
|Principal Investigator:||Kresimir Banovac, PhD MD||VA Spinal Cord Injury Service|