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Cognitive Remediation and Social Skills Training in Schizophrenia

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ClinicalTrials.gov Identifier: NCT00223535
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : September 22, 2005
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to examine whether patients who participate in cognitive remediation prior to a skills training program learn and perform the skills better than patients who do not participate in cognitive remediation.

Condition or disease Intervention/treatment
Schizophrenia Schizoaffective Behavioral: Cognitive Remediation Behavioral: Social Skills Training

Detailed Description:

Subjects are 40 stable outpatients with schizophrenia or schizoaffective disorder who are receiving medication and routine follow-up care at community clinics in San Antonio, Texas.

Patients receive baseline assessments and then are randomly assigned to either Cognitive Remediation (CR) or Keyboarding Skills (KS) for a period of 8 weeks. Following 8 weeks of treatment in either CR or KS, all patients participated in Social Skills Training (SST) for a period of 8 weeks. Assessments conducted by raters blinded to treatment condition are repeated following either remediation or control treatment, and again following SST.

Treatment groups Cognitive Remediation (CR) -- The CR program is based upon teaching techniques developed within educational psychology that promote intrinsic motivation and task engagement. The program uses existing computer software packages (e.g., Oregon Trail) with engaging story lines or activities, and built-in reinforcement of correct responses to help patients with schizophrenia develop attention, memory, planning, and problem-solving skills. CR is delivered in a computer lab setting with a facilitator present to assist patients.

Keyboarding Skills (KS) -- Control Treatment: The control treatment is an engaging self-paced software program designed to teach typing skills. KS is delivered in a computer lab setting with a facilitator present.

Both the KS and CR are administered in small groups of three to five patients each.

Social Skills Training (SST) -- SST is a manual-driven, behavioral rehabilitation program teaching basic conversation and social problem-solving skills (Bellack et al., 1997). SST runs for 8 weeks and is conducted in small groups that meet twice weekly.

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Cognitive Remediation and Social Skills Training in Schizophrenia
Study Start Date : February 2003
Estimated Study Completion Date : March 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia
U.S. FDA Resources

Arms and Interventions

Outcome Measures

Primary Outcome Measures :
  1. Scores on tests of cognitive functioning

Secondary Outcome Measures :
  1. Outcomes on tests of social functioning after SST

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of schizophrenia/schizoaffective disorder
  • currently receiving treatment with an atypical antipsychotic medication
  • between the ages of 18 and 60 years
  • speak English as their primary language
  • has at least a 6th grade level of reading (WRAT) Exclusion Criteria
  • no current diagnosis of substance abuse or dependence
  • no documented history of head injury, epilepsy or mental retardation.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00223535

United States, Texas
San Antonio, Texas, United States, 78229
Sponsors and Collaborators
The University of Texas Health Science Center at San Antonio
National Alliance for Research on Schizophrenia and Depression
Principal Investigator: Dawn I Velligan, Ph.D. University of Texas
More Information

ClinicalTrials.gov Identifier: NCT00223535     History of Changes
Other Study ID Numbers: 012-0013-164
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: September 22, 2005
Last Verified: September 2005

Keywords provided by The University of Texas Health Science Center at San Antonio:
Cognitive Remediation
Social Skills Training

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders