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Impact of Caregiver Depression on Asthma in the Child

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00223288
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : August 3, 2011
Information provided by:

Study Description
Brief Summary:

This study will examine if depression in a primary caregiver is associated with more hospitalization or ER visits in children with asthma. This study will also explore whether treatment for depression in the primary caregivers is associated with improvement in asthma in school-aged children.

Asthma is a very common childhood disorder of airway inflammation. The causes include environmental irritants, cold temperature, and infection in the respiratory tract, and emotional factors can contribute to symptom exacerbation. However, asthma is a disease that can be well controlled if there is proper medication compliance and careful control of environmental conditions.

Data suggests that psychiatric symptoms in the mothers of children with asthma are associated with more asthma related hospitalizations in children. Thus, we want to explore this question further using more specific diagnostic instruments in order to detect what types of symptoms are associated with increased asthma related service utilization. Also, we want to explore if effective treatment of the caregivers' symptoms is associated with decreased hospitalization and emergency room visits for the child.

Condition or disease Intervention/treatment Phase
Depressive Disorder, Major Asthma Drug: Lexapro Phase 4

Study Design

Study Type : Observational
Estimated Enrollment : 175 participants
Official Title: Caregiver Psychiatric Symptomatology and it's Relationship to Service Utilization by Children With Asthma
Study Start Date : March 2003
Primary Completion Date : February 2006
Study Completion Date : February 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma Caregivers
Drug Information available for: Citalopram
U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
Primary caregiver of a child currently hospitalized at Children's Medical Center of Dallas for an asthma exacerbation and between the ages of 5 and 16 years old

Inclusion Criteria:

  • Primary caregiver of a child currently hospitalized at Children's Medical Center of Dallas for an asthma exacerbation and between the ages of 5 and 16 years old
  • Male and female
  • English or Spanish Speaking
  • Between the ages of 18 and 70 years old
  • Caregivers with major depressive disorder will be offered treatment

Exclusion Criteria:

  • At risk for suicide defined by multiple suicide attempts (greater than or equal to 3 in the past), and/or current suicidal ideation with a well-formed plan or intent
  • Unlikely to attend follow-up appointments
  • Mentally retarded or suffer from other severe cognitive impairment
  • Pregnant or nursing, or women of childbearing age who will not use methods of birth control or abstinence during the study
  • Suffering from a severe or life-threatening medical illness which would make completion of the study unlikely
  • Suffering from treatment refractory depression defined by failing three adequate trials of antidepressants
  • Depression as part of bipolar disorder or schizophrenia or schizoaffective disorder, or current depression secondary to a medication or general medical condition, or with psychotic features
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00223288

United States, Texas
The University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75235
Sponsors and Collaborators
University of Texas Southwestern Medical Center
Principal Investigator: E. Sherwood Brown, MD, Ph.D. University of Texas, Southwestern Medical Center at Dallas
More Information

Responsible Party: Sherwood Brown PI, UT Southwestern Medical Center at Dallas
ClinicalTrials.gov Identifier: NCT00223288     History of Changes
Other Study ID Numbers: MHGP MM12
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: August 3, 2011
Last Verified: August 2011

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Mood Disorders
Mental Disorders
Behavioral Symptoms
Serotonin Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Serotonin Agents
Physiological Effects of Drugs
Antidepressive Agents, Second-Generation
Antidepressive Agents
Psychotropic Drugs