Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis
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|ClinicalTrials.gov Identifier: NCT00222534|
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : January 20, 2014
Respiratory failure is a common consequence of chronic obstructive pulmonary disease (COPD). A concurrent metabolic alkalosis may worsen the respiratory failure, as a higher pH in blood (and thus in cerebrospinal fluid) results in a weaker respiratory drive. Use of diuretics is the most common cause of metabolic alkalosis.
When a patient with an acute exacerbation of a respiratory failure is also alkalotic, there are (at least theoretical) reasons to lower the pH in order to increase the respiratory drive. Among other alternatives, the drug acetazolamide can be used for this purpose.
In some hospitals there is a tradition for the use of acetazolamide on this indication, but any evidence for the effect of such a treatment is rather weak.
Thus, the aim of this trial is to evaluate the effect of acetazolamide as an adjuvant treatment for hospitalized patients with acute exacerbation of respiratory failure in combination with metabolic alkalosis.
|Condition or disease||Intervention/treatment||Phase|
|Respiratory Insufficiency Alkalosis||Drug: Acetazolamide Drug: Placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||70 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis|
|Study Start Date :||January 2002|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||December 2009|
Acetazolamide 250 mg Three times a day for five days
Placebo Comparator: Placebo
Placebo, one tablet Three times a day for five days
- Partial pressure of oxygen in arterial blood on the 5th day of treatment (without extra oxygen)
- Change in partial pressure of oxygen from start of treatment to the fifth day of treatment
- Partial pressure of carbon dioxide in arterial blood on the 5th day of treatment.
- Change in partial pressure of carbon dioxide from start of treatment to the fifth day of treatment
- Intrahospital deaths
- Use of mechanical ventilation
- Length of stay
- Side effects
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00222534
|Department of Respiratory Medicine, Haukeland University Hospital|
|Department of Internal Medicine, Sorlandet Sykehus Kristiansand|
|Department of Internal Medicine, Aker University Hospital|
|Oslo, Norway, 0514|
|Ullevaal University Hospital, Dept. of Respiratory Medicine|
|Oslo, Norway, NO-0407|
|Department of Internal Medicine, St.Olav's Hospital|
|Principal Investigator:||Torgeir B Wyller, MD, PhD||Department of Geriatric Medicine, Ullevaal University Hospital, Oslo, Norway|