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Depakote ER in Borderline Personality Disorder

This study has been completed.
Schulz, S. Charles, M.D.
Information provided by:
University of Minnesota - Clinical and Translational Science Institute Identifier:
First received: September 14, 2005
Last updated: August 8, 2007
Last verified: August 2007
This study examines the effect of Depakote ER versus placebo in a randomized trial of borderline personality disorder. Patients all participate in DBT therapy and those who are not responsive are assigned to either Depakote ER or placebo for up to 12 weeks. Borderline Personality Symtoms are measured and side-effects are assessed.

Condition Intervention
Borderline Personality Disorder
Drug: Depakote ER

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: A Double-Blind and Placebo Controlled Assessment of Depakote ER in Borderline Personality Disorder

Resource links provided by NLM:

Further study details as provided by University of Minnesota - Clinical and Translational Science Institute:

Primary Outcome Measures:
  • Symptom Checklist 90

Secondary Outcome Measures:
  • Barratt Impulsivity Scale

Estimated Enrollment: 15
Study Start Date: March 2003
Study Completion Date: September 2005

Ages Eligible for Study:   21 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:Male or female patients with the diagnosis of borderline personality disorder between the ages of 21 adn 55 years old. Must be in good physical health -

Exclusion Criteria:Major psychiatric illness on Axis I - schizophrenia or bipolar disorder. May not have current MDD. May not be dependent on illicit substances or alcohol.

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Please refer to this study by its identifier: NCT00222482

Sponsors and Collaborators
University of Minnesota - Clinical and Translational Science Institute
Schulz, S. Charles, M.D.
Principal Investigator: Sellamnn C Schulz, M.D. Department of Psychiatry, University of Minnesota Medical School
  More Information

Publications: Identifier: NCT00222482     History of Changes
Other Study ID Numbers: 0306M49703
Study First Received: September 14, 2005
Last Updated: August 8, 2007

Keywords provided by University of Minnesota - Clinical and Translational Science Institute:
Borderline Personality Disorder

Additional relevant MeSH terms:
Personality Disorders
Borderline Personality Disorder
Pathologic Processes
Mental Disorders
Valproic Acid
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
GABA Agents
Neurotransmitter Agents
Physiological Effects of Drugs
Antimanic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs processed this record on May 22, 2017