Diagnostic Innovations in Glaucoma Study (DIGS)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00221897|
Recruitment Status : Unknown
Verified August 2011 by University of California, San Diego.
Recruitment status was: Recruiting
First Posted : September 22, 2005
Last Update Posted : August 30, 2011
|Condition or disease|
|Primary Open Angle Glaucoma|
The purpose of the study is:
- To further determine the nature of vision loss and optic nerve structural change associated with glaucoma. Using recently developed psychophysical and imaging techniques, we will continue use of a multivariate approach for analysis of the functional and structural changes associated with glaucoma to delineate further the relationship of these changes to the underlying physiological mechanisms associated with magnocellular, small bistratified "blue-yellow", and parvocellular neural pathways.
- To evaluate and improve new diagnostic and monitoring techniques encompassing measures of visual function and optic nerve and retina nerve fiber layer structure and to compare the rate and patterns of progression of glaucomatous damage
- To improve techniques for evaluation of current management and new therapies for glaucoma as they become available. We will expand our analysis using multivariate techniques incorporating visual function, optic nerve structure, and various risk factors to improve detection of true change.
- To determine the quantitative temporal relationships between recognizable optic nerve damage and measurable visual field loss. Using new techniques with improved sensitivity, the detection and monitoring of early optic disc defects may provide profiles of people at risk for developing glaucomatous visual function loss thus better defining target populations for treatment.
SPECIFIC AIMS OF DIGS: STRUCTURAL ASSESSMENT Overall Aim: Develop improved methods to 1) detect the onset and progression of structural damage due to glaucoma, and 2) to measure the rate of glaucomatous progression and its determinants, and 3) characterize the relationship between structural and functional change over time. In addition, a major goal of this research is to develop methods to shorten the time frame needed to identify and verify progression of optic disc and retinal nerve fiber damage.
SPECIFIC AIMS OF DIGS: VISUAL FUNCTION Overall Aim: Develop improved measures to detect the onset and progression of glaucoma, to assess treatment effectiveness, and to validate predictive genetic testing using psychophysical measures of visual function.
|Study Type :||Observational|
|Estimated Enrollment :||3000 participants|
|Official Title:||Diagnostic Innovations in Glaucoma Study|
|Study Start Date :||April 1995|
|Estimated Study Completion Date :||July 2016|
|Persons at risk for or with primary open angle glaucoma|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00221897
|Contact: Eunice Williams-Steppe, MAemail@example.com|
|Contact: Cheryl Rudy-Goodness, MPHfirstname.lastname@example.org|
|United States, California|
|UCSD, Hamilton Glaucoma Center||Recruiting|
|La Jolla, California, United States, 92093-0946|
|Contact: Eunice Williams-Steppe, MA 858-822-1133 email@example.com|
|Contact: Cecelia Gastelum, MPH 858-534-6714 firstname.lastname@example.org|
|Principal Investigator: Linda M Zangwill, PhD|
|Sub-Investigator: Robert N Weinreb, MD|
|Principal Investigator: Felipe Medeiros, MD|
|Sub-Investigator: Christopher Bowd, PhD|
|Principal Investigator:||Linda Zangwill, PhD||University of California, San Diego|
|Principal Investigator:||Felipe Medeiros, MD||University of California, San Diego|