Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
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ClinicalTrials.gov Identifier: NCT00221832 |
Recruitment Status
: Unknown
Verified October 2003 by Heidelberg University.
Recruitment status was: Recruiting
First Posted
: September 22, 2005
Last Update Posted
: January 13, 2010
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Condition or disease |
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Long QT Syndrome Hypertrophic Cardiomyopathy Arrhythmogenic Right Ventricular Dysplasia |
Molecular genetic screening in patients with:
- supraventricular
- ventricular arrhythmia
- syncopes of unknown origin and/or suspicion of an arrhythmogenic origin
- family members of patients with sudden cardiac death and aborted sudden cardiac death
Examination of patients includes routine testing like electrocardiogram (ECG), sequential ECGs, exercise testing, invasive electrophysiological stimulation, cardiac magnetic resonance imaging, intravenous drug challenge for identification/exclusion of eg Brugada syndrome. Examples are patients with Long QT Syndrome, Short QT Syndrome, Brugada Syndrome, familial atrial fibrillation, WPW-syndrome, arrhythmias due to familial hypertrophic cardiomyopathy or arrhythmogenic right ventricular dysplasia. Blood samples are taken for further molecular genetic screening.
Study Type : | Observational |
Estimated Enrollment : | 300 participants |
Observational Model: | Family-Based |
Time Perspective: | Prospective |
Official Title: | Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases |
Study Start Date : | October 2003 |
Estimated Study Completion Date : | December 2011 |


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Ages Eligible for Study: | Child, Adult, Senior |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Patients with a history of syncope, abnormal ECG and suspicion of an arrhythmogenic disease
- Patients with long QT syndrome
- Patients with short QT syndrome, shortened QT intervals, borderline shortened QT intervals
- Patients with Brugada syndrome
- Patients with hypertrophic cardiomyopathy
- Patients with arrhythmogenic right ventricular dysplasia
Exclusion Criteria:
- Inability to understand study protocol

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00221832
Contact: Christian Wolpert, MD | +49-621-383-2206 | christian.wolpert@med.ma.uni-heidelberg.de | |
Contact: Rainer Schimpf, MD | +49-621-383-2206 | rainer.schimpf@med.ma.uni-heidelberg.de |
Germany | |
University Hospital Mannheim, I. Department of Medicine | Recruiting |
Mannheim, Germany, 68167 | |
Contact: Christian Wolpert, MD +49-621-3832206 christian.wolpert@med.ma.uni-heidelberg.de | |
Contact: Rainer Schimpf, MD +49-621-3832206 rainer.schimpf@med.ma.uni-heidelberg.de | |
Principal Investigator: Christian Wolpert, MD |
Study Director: | Martin Borggrefe, Prof., MD | I. Department of Medicine-Cardiology |
Responsible Party: | Prof. C. Wolpert, I. Department of Medicine-Cardiology, University Hospital Mannheim, . Department of Medicine-Cardiology, University Hospital Mannheim |
ClinicalTrials.gov Identifier: | NCT00221832 History of Changes |
Other Study ID Numbers: |
0261.5 |
First Posted: | September 22, 2005 Key Record Dates |
Last Update Posted: | January 13, 2010 |
Last Verified: | October 2003 |
Keywords provided by Heidelberg University:
Long QT Syndrome Hypertrophic cardiomyopathy arrhythmogenic right ventricular dysplasia Short QT Syndrome Brugada Syndrome |
Additional relevant MeSH terms:
Long QT Syndrome Syndrome Cardiomyopathies Hypertrophy Cardiomyopathy, Hypertrophic Arrhythmogenic Right Ventricular Dysplasia Disease Pathologic Processes Heart Diseases |
Cardiovascular Diseases Pathological Conditions, Anatomical Aortic Stenosis, Subvalvular Aortic Valve Stenosis Heart Valve Diseases Arrhythmias, Cardiac Heart Defects, Congenital Cardiovascular Abnormalities Congenital Abnormalities |