Gases Humidification During Noninvasive Ventilation : Heat and Moisture Exchanger or Heated Humidifier ?
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|ClinicalTrials.gov Identifier: NCT00221819|
Recruitment Status : Terminated
First Posted : September 22, 2005
Last Update Posted : May 9, 2013
|Condition or disease||Intervention/treatment||Phase|
|Acute Lung Injury Pneumonia Chronic Obstructive Pulmonary Disease Acute Heart Failure||Device: heated humidifier (device) Device: Heat and moisture exchanger (device)||Not Applicable|
Objective: Few data are reported in the field of noninvasive ventilation (NIV) regarding humidification devices. It was previously suggested that standard heat and moisture exchangers (HME) had adverse gasometrical and clinical outcomes in acute respiratory failure (ARF) of chronic respiratory failure patients (CRF). This study was performed to evaluate respiratory parameters and arterial blood gases (ABG) of patients during NIV with small dead space HME compared to heated humidifier (HH).
Design: Prospective randomized cross-over study. Setting: A 16-bed medical intensive care unit (ICU) and a 14-bed medico surgical ICU.
Patients: Patients receiving NIV for ARF in the context of CRF or hypoxic ARF and patients with persistent weaning failure receiving NIV just after extubation.
Measurements: HME and HH were randomly compared during 2 NIV periods of 30 minutes separated by a 20 to 30 minutes period of spontaneous breathing with oxygen. ABG were collected at baseline and at the end of each period. As well as respiratory parameters including volumes, pressures, P0.1, a comfort score, capnometry and oxygen saturation. Two sets of patients were successively studied whether they have a flex tube added to the ventilatory circuit or not.
|Study Type :||Interventional (Clinical Trial)|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Prospective Study of the Influence of the Humidification Mode on Ventilation Parameters and Arterial Blood Gases in Non Invasive Ventilation|
|Study Start Date :||June 2004|
|Actual Primary Completion Date :||December 2004|
|Actual Study Completion Date :||December 2004|
- Air blood gases at the end of each study period (one with HME, one with HH)
- Respiratory parameters including volumes, pressures, P0.1, a comfort score, capnometry and oxygen saturation at the end of each study period (one with HME, one with HH)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00221819
|Département de Réanimation Médicale, Hôpital Pellegrin-Tripode, Place A. Raba Léon,|
|Bordeaux, France, 33076|
|Principal Investigator:||alexandre Boyer, Dr||University Hospital, Bordeaux|