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Role of Left Ventricular Pacing Site

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2007 by University Hospital, Bordeaux.
Recruitment status was:  Recruiting
Ministry of Health, France
Information provided by:
University Hospital, Bordeaux Identifier:
First received: September 13, 2005
Last updated: June 28, 2007
Last verified: June 2007
Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. We study in a random order 11 different left ventricular pacing sites and compare their hemodynamics using pressure-volume catheters. The consequences on the surface ECG are also assessed.

Condition Intervention
Heart Failure
Cardiomyopathy, Dilated
Coronary Disease
Device: left ventricular pacing

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind
Primary Purpose: Treatment
Official Title: Importance of Left Ventricular Pacing Site in Biventricular Resynchronization Therapy for Severe Heart Failure

Resource links provided by NLM:

Further study details as provided by University Hospital, Bordeaux:

Primary Outcome Measures:
  • Variation in left ventricular dp/dt max

Secondary Outcome Measures:
  • pressures and volumes of the left ventricle
  • stroke work
  • surface ECG repolarisation

Estimated Enrollment: 33
Study Start Date: November 2003
Estimated Study Completion Date: December 2007
Detailed Description:

Background. Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site.

Design. Single-blind, monocentric, randomized cross-over study comparing 11 left ventricular pacing sites in a random order.

Intervention. Left ventricular DDD pacing on 11 ventricular sites, prior to the implantation. At each pacing site, a control hemodynamics will be obtained in AAI pacing at the same pacing rate. At each pacing site, 2 AV delays, a short and a long one, will be assessed.

Eligibility criteria. Patients referred for cardiac resynchronization therapy for heart failure

Outcomes. Hemodynamic measures using pressure-volume catheters.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Heart failure referred for cardiac resynchronization therapy
  • NYHA Class III or IV
  • Informed consent form signed

Exclusion Criteria:

  • Hypertension not controlled by treatment
  • Coronary ischemia not controlled by treatment
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Please refer to this study by its identifier: NCT00221780

Hôpital Cardiologique du Haut Lévêque, Rythmology department, Pr CLEMENTY, 3rd Floor
Pessac, France, 33604
Sponsors and Collaborators
University Hospital, Bordeaux
Ministry of Health, France
Principal Investigator: Pierre Jaïs, Dr University Hospital, Bordeaux
Study Chair: Paul Perez, Dr University Hospital, Bordeaux
  More Information Identifier: NCT00221780     History of Changes
Other Study ID Numbers: 9426-01  2001-030 
Study First Received: September 13, 2005
Last Updated: June 28, 2007
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by University Hospital, Bordeaux:
Heart failure
Cardiomyopathy, dilated
Coronary disease
Cardiac Pacing, Artificial
Randomized Controlled Trials
Single-Blind Study

Additional relevant MeSH terms:
Heart Failure
Coronary Disease
Coronary Artery Disease
Cardiomyopathy, Dilated
Heart Diseases
Cardiovascular Diseases
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases
Cardiomegaly processed this record on December 08, 2016