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Perioperative Epidural Trial (POET) Pilot Study

This study has been completed.
Canadian Institutes of Health Research (CIHR)
Information provided by:
University of British Columbia Identifier:
First received: September 18, 2005
Last updated: September 24, 2008
Last verified: September 2008
To investigate if the use of perioperative neuraxial blockade reduces post-operative mortality and cardiorespiratory events compared to intraoperative general anesthesia AND postoperative IV narcotic analgesia. This is a feasibility study to determine if recruitment and execution of the protocol could be done in a timely manner in a much larger trial

Condition Intervention
Post Operative Pain Control
Procedure: anesthesia

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Treatment
Official Title: Perioperative Epidural Trial (POET) Pilot Study

Resource links provided by NLM:

Further study details as provided by University of British Columbia:

Primary Outcome Measures:
  • Combined mortality, MI, cardiac arrest, post operative pneumonia , and respiratory failure [ Time Frame: Unspecified ]

Secondary Outcome Measures:
  • DVT, pulmonary embolism, TIA, CVA, CHF, clinically significant bradycardia/hypotension [ Time Frame: Unspecified ]

Estimated Enrollment: 250
Study Start Date: September 2005
Study Completion Date: January 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: anesthesia
    Intraoperative general anesthesia AND postoperative IV narcotic analgesia.

Ages Eligible for Study:   45 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Subjects at high risk of cardio-respiratory complications post operatively.

Exclusion Criteria:

Contraindication to epidural anesthesia

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Please refer to this study by its identifier: NCT00221260

Canada, British Columbia
Vancouver General Hospital, Clinical Health Research Unit
Vancouver, British Columbia, Canada, V5Z 1L8
Sponsors and Collaborators
University of British Columbia
Canadian Institutes of Health Research (CIHR)
Principal Investigator: Peter Choi, MD University of British Columbia
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Dr. Peter Choi, University of British Columbia Identifier: NCT00221260     History of Changes
Other Study ID Numbers: C04-0078
Study First Received: September 18, 2005
Last Updated: September 24, 2008

Keywords provided by University of British Columbia:

Additional relevant MeSH terms:
Pain, Postoperative
Neurologic Manifestations
Nervous System Diseases
Postoperative Complications
Pathologic Processes
Signs and Symptoms
Central Nervous System Depressants
Physiological Effects of Drugs processed this record on April 28, 2017