Prevention of Postoperative Delirium With Donepezil
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Patients undergoing hip or knee joint replacement at the age of 70 years or above who are cognitively unimpaired will receive donepezil or matching placebo before (over 5-7 days), during and after (over 7 days) surgery. The incidence of delirium will be monitored at 3 days, 7 days, and 49 days following surgery. We hypothesize that the incidence of delirium can be lowered from 20 per cent to 10 per cent by the intervention.
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Ages Eligible for Study:
70 Years and older (Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Cognitively healthy, elective hip or knee replacement