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Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2007 by Radboud University.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00220246
First Posted: September 22, 2005
Last Update Posted: March 1, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Radboud University
  Purpose
Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

Condition
Colorectal Neoplasms

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Retrospective

Resource links provided by NLM:


Further study details as provided by Radboud University:

Estimated Enrollment: 130
Study Start Date: March 2004
Estimated Study Completion Date: September 2008
Detailed Description:
Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 51 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

- Colorectal cancer before the age of 51 years

Microsatellite stable tumor

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00220246


Locations
Netherlands
Radboud University
Nijmegen, Netherlands
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Nicoline Hoogerbrugge, MD, PhD Department of Human Genetics, Radboud University Nijmegen Medical Center
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00220246     History of Changes
Other Study ID Numbers: EOMSD2004
First Submitted: September 20, 2005
First Posted: September 22, 2005
Last Update Posted: March 1, 2007
Last Verified: February 2007

Keywords provided by Radboud University:
Hereditary colorectal cancer
Microsatellite instability
Chromosomal instability

Additional relevant MeSH terms:
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases