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Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00220246
Recruitment Status : Unknown
Verified February 2007 by Radboud University.
Recruitment status was:  Active, not recruiting
First Posted : September 22, 2005
Last Update Posted : March 1, 2007
Information provided by:
Radboud University

Brief Summary:
Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.

Condition or disease
Colorectal Neoplasms

Detailed Description:
Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.

Study Type : Observational
Estimated Enrollment : 130 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Retrospective
Study Start Date : March 2004
Estimated Study Completion Date : September 2008

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Information from the National Library of Medicine

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Ages Eligible for Study:   up to 51 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

- Colorectal cancer before the age of 51 years

Microsatellite stable tumor

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00220246

Radboud University
Nijmegen, Netherlands
Sponsors and Collaborators
Radboud University
Principal Investigator: Nicoline Hoogerbrugge, MD, PhD Department of Human Genetics, Radboud University Nijmegen Medical Center

Publications: Identifier: NCT00220246     History of Changes
Other Study ID Numbers: EOMSD2004
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: March 1, 2007
Last Verified: February 2007

Keywords provided by Radboud University:
Hereditary colorectal cancer
Microsatellite instability
Chromosomal instability

Additional relevant MeSH terms:
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases