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Exercise-training Before Coronary Artery Bypass Graft (CABG)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00218985
First received: September 20, 2005
Last updated: February 14, 2017
Last verified: February 2017
  Purpose
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Condition Intervention
Angina
Coronary Artery Disease
Behavioral: Exercise training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Investigator
Primary Purpose: Basic Science
Official Title: Exercise-training Before Coronary Artery Bypass Graft (CABG)

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Cardiovascular function and quality of life [ Time Frame: Before and up to 1 year after intervention ]

Secondary Outcome Measures:
  • Structure and function of cardiomyocytes [ Time Frame: After the intervention period ]
  • Cardiomyocyte structure and function [ Time Frame: after the intervention period ]

Enrollment: 40
Actual Study Start Date: January 2005
Study Completion Date: December 2016
Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: exercise training Behavioral: Exercise training
Intensity controlled exercise training before the scheduled bypass surgery
No Intervention: physician's advice
patients follow their physician's advice in regard to physical activity.

  Eligibility

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Scheduled for CABG both with and without heart failure

Exclusion Criteria:

  • Unstable angina
  • Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
  • Participation in another study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00218985

Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology
  More Information

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00218985     History of Changes
Other Study ID Numbers: TRIM 158-04
Study First Received: September 20, 2005
Last Updated: February 14, 2017

Keywords provided by Norwegian University of Science and Technology:
Aerobic capacity
Exercise training
CABG
Endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on March 27, 2017