Exercise-training Before Coronary Artery Bypass Graft (CABG)
This study is currently recruiting participants.
(see Contacts and Locations)
Verified August 2016 by Norwegian University of Science and Technology
Sponsor:
Norwegian University of Science and Technology
Information provided by (Responsible Party):
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00218985
First received: September 20, 2005
Last updated: August 16, 2016
Last verified: August 2016
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Purpose
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.
| Condition | Intervention |
|---|---|
|
Angina Coronary Artery Disease |
Behavioral: Exercise training |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Investigator) Primary Purpose: Basic Science |
| Official Title: | Exercise-training Before Coronary Artery Bypass Graft (CABG) |
Resource links provided by NLM:
Further study details as provided by Norwegian University of Science and Technology:
Primary Outcome Measures:
- Cardiovascular function and quality of life [ Time Frame: Before and up to 1 year after intervention ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Structure and function of cardiomyocytes [ Time Frame: After the intervention period ] [ Designated as safety issue: No ]
- Cardiomyocyte structure and function [ Time Frame: after the intervention period ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 40 |
| Study Start Date: | January 2005 |
| Estimated Study Completion Date: | December 2016 |
| Estimated Primary Completion Date: | December 2016 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: exercise training |
Behavioral: Exercise training
Intensity controlled exercise training before the scheduled bypass surgery
|
|
No Intervention: physician's advice
patients follow their physician's advice in regard to physical activity.
|
Eligibility| Ages Eligible for Study: | Child, Adult, Senior |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Scheduled for CABG both with and without heart failure
Exclusion Criteria:
- Unstable angina
- Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
- Participation in another study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00218985
Please refer to this study by its ClinicalTrials.gov identifier: NCT00218985
Contacts
| Contact: Ulrik Wisloff, Ph.D | +4773598621 | ulrik.wisloff@ntnu.no | |
| Contact: Øyvind Ellingsen, Ph.D, MD | oyvind.ellingsen@ntnu.no |
Locations
| Norway | |
| Norwegian University of Science and Technology | Recruiting |
| Trondheim, Norway, 7489 | |
| Contact: Ulrik Wisloff, Ph.D ulrik.wisloff@ntnu.no | |
| Principal Investigator: Ulrik Wisloff, Ph.D | |
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
| Principal Investigator: | Ulrik Wisloff, Ph.D | Norwegian University of Science and Technology |
More Information
| Responsible Party: | Norwegian University of Science and Technology |
| ClinicalTrials.gov Identifier: | NCT00218985 History of Changes |
| Other Study ID Numbers: | TRIM 158-04 |
| Study First Received: | September 20, 2005 |
| Last Updated: | August 16, 2016 |
| Health Authority: | Norway: Norwegian Social Science Data Services |
Keywords provided by Norwegian University of Science and Technology:
|
Aerobic capacity Exercise training CABG Endothelial function |
Additional relevant MeSH terms:
|
Coronary Artery Disease Myocardial Ischemia Coronary Disease Heart Diseases |
Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases |
ClinicalTrials.gov processed this record on September 23, 2016