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Exercise-training Before Coronary Artery Bypass Graft (CABG)

This study has been completed.

Sponsor:

ClinicalTrials.gov Identifier:

NCT00218985

First Posted: September 22, 2005

Last Update Posted: February 15, 2017

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

Information provided by (Responsible Party):

Norwegian University of Science and Technology

Purpose

The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Condition	Intervention
Angina Coronary Artery Disease	Behavioral: Exercise training


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Investigator) Primary Purpose: Basic Science
Official Title:	Exercise-training Before Coronary Artery Bypass Graft (CABG)

Resource links provided by NLM:

MedlinePlus related topics: Coronary Artery Bypass Surgery Exercise and Physical Fitness

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:

Cardiovascular function and quality of life [ Time Frame: Before and up to 1 year after intervention ]

Secondary Outcome Measures:

Structure and function of cardiomyocytes [ Time Frame: After the intervention period ]
Cardiomyocyte structure and function [ Time Frame: after the intervention period ]


Enrollment:	40
Actual Study Start Date:	January 2005
Study Completion Date:	December 2016
Primary Completion Date:	December 2016 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: exercise training	Behavioral: Exercise training Intensity controlled exercise training before the scheduled bypass surgery
No Intervention: physician's advice patients follow their physician's advice in regard to physical activity.

Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:	Child, Adult, Senior
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Scheduled for CABG both with and without heart failure

Exclusion Criteria:

Unstable angina
Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
Participation in another study

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00218985

Locations


Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489

Sponsors and Collaborators

Norwegian University of Science and Technology

Investigators


Principal Investigator:	Ulrik Wisloff, Ph.D	Norwegian University of Science and Technology

More Information


Responsible Party:	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00218985 History of Changes
Other Study ID Numbers:	TRIM 158-04
First Submitted:	September 20, 2005
First Posted:	September 22, 2005
Last Update Posted:	February 15, 2017
Last Verified:	February 2017

Keywords provided by Norwegian University of Science and Technology:


Aerobic capacity Exercise training CABG Endothelial function

Additional relevant MeSH terms:


Coronary Artery Disease Myocardial Ischemia Coronary Disease Heart Diseases	Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases

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