ClinicalTrials.gov
ClinicalTrials.gov Menu

Exercise-training Before Coronary Artery Bypass Graft (CABG)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00218985
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : February 20, 2018
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Study Description
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Condition or disease Intervention/treatment Phase
Angina Coronary Artery Disease Behavioral: Exercise training Not Applicable

Study Design
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Exercise-training Before Coronary Artery Bypass Graft (CABG)
Actual Study Start Date : January 2005
Actual Primary Completion Date : December 2016
Actual Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Arm Intervention/treatment
Experimental: exercise training Behavioral: Exercise training
Intensity controlled exercise training before the scheduled bypass surgery
No Intervention: physician's advice
patients follow their physician's advice in regard to physical activity.


Outcome Measures
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Cardiovascular function and quality of life [ Time Frame: Before and up to 1 year after intervention ]

Secondary Outcome Measures :
  1. Structure and function of cardiomyocytes [ Time Frame: After the intervention period ]
  2. Cardiomyocyte structure and function [ Time Frame: after the intervention period ]

Eligibility Criteria
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Scheduled for CABG both with and without heart failure

Exclusion Criteria:

  • Unstable angina
  • Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
  • Participation in another study
Contacts and Locations
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00218985


Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology
More Information
Go to 
Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications of Results:

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00218985     History of Changes
Other Study ID Numbers: TRIM 158-04
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: February 20, 2018
Last Verified: February 2018

Keywords provided by Norwegian University of Science and Technology:
Aerobic capacity
Exercise training
CABG
Endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
 Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases