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Exercise-training Before Coronary Artery Bypass Graft (CABG)

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ClinicalTrials.gov Identifier: NCT00218985
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : February 20, 2018
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Condition or disease Intervention/treatment
Angina Coronary Artery Disease Behavioral: Exercise training

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Exercise-training Before Coronary Artery Bypass Graft (CABG)
Actual Study Start Date : January 2005
Primary Completion Date : December 2016
Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: exercise training Behavioral: Exercise training
Intensity controlled exercise training before the scheduled bypass surgery
No Intervention: physician's advice
patients follow their physician's advice in regard to physical activity.



Primary Outcome Measures :
  1. Cardiovascular function and quality of life [ Time Frame: Before and up to 1 year after intervention ]

Secondary Outcome Measures :
  1. Structure and function of cardiomyocytes [ Time Frame: After the intervention period ]
  2. Cardiomyocyte structure and function [ Time Frame: after the intervention period ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Scheduled for CABG both with and without heart failure

Exclusion Criteria:

  • Unstable angina
  • Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
  • Participation in another study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00218985


Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology

Publications:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00218985     History of Changes
Other Study ID Numbers: TRIM 158-04
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: February 20, 2018
Last Verified: February 2018

Keywords provided by Norwegian University of Science and Technology:
Aerobic capacity
Exercise training
CABG
Endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases