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Exercise-training Before Coronary Artery Bypass Graft (CABG)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00218985
First Posted: September 22, 2005
Last Update Posted: February 15, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Norwegian University of Science and Technology
  Purpose
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

Condition Intervention
Angina Coronary Artery Disease Behavioral: Exercise training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Exercise-training Before Coronary Artery Bypass Graft (CABG)

Resource links provided by NLM:


Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • Cardiovascular function and quality of life [ Time Frame: Before and up to 1 year after intervention ]

Secondary Outcome Measures:
  • Structure and function of cardiomyocytes [ Time Frame: After the intervention period ]
  • Cardiomyocyte structure and function [ Time Frame: after the intervention period ]

Enrollment: 40
Actual Study Start Date: January 2005
Study Completion Date: December 2016
Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: exercise training Behavioral: Exercise training
Intensity controlled exercise training before the scheduled bypass surgery
No Intervention: physician's advice
patients follow their physician's advice in regard to physical activity.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Scheduled for CABG both with and without heart failure

Exclusion Criteria:

  • Unstable angina
  • Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
  • Participation in another study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00218985


Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7489
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology
  More Information

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00218985     History of Changes
Other Study ID Numbers: TRIM 158-04
First Submitted: September 20, 2005
First Posted: September 22, 2005
Last Update Posted: February 15, 2017
Last Verified: February 2017

Keywords provided by Norwegian University of Science and Technology:
Aerobic capacity
Exercise training
CABG
Endothelial function

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases