Buprenorphine as a Treatment for Individuals Dependent on Analgesic Opioids
Opioids used to treat chronic pain have a high abuse potential. The purpose of this study is to determine the effectiveness of buprenorphine in treating opioid dependent individuals who abuse opioids that are prescribed for chronic pain.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Dose Reduction Strategies in Oral Opioid Dependence Subsequent to Pain Management: An Exploratory Study|
- Substance use
- medication compliance
- treatment retention
- Behavioral and psychological measures (measured during the dose reduction phase)
|Study Start Date:||May 2004|
|Estimated Study Completion Date:||March 2005|
Many individuals who take opioids for chronic pain abuse the opioid medication. Buprenorphine is an opioid partial agonist that may be effective in treating individuals who abuse opiate pain medication. The purpose of this study is to compare two buprenorphine dosing regimens in order to determine which regimen is more effective in reducing opiate pain medication use and facilitating successful opioid detoxification.
This study will last 27 weeks. Participants will receive a maintenance dose of 8 mg of buprenorphine for 6 weeks, followed by a dose reduction in 2 mg increments over the course of the following 20 weeks. All participants will attend weekly clinical management sessions for the duration of the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00218101
|United States, Texas|
|University of Texas Health Science Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||John Grabowski, PhD||University of Texas|