Impulsivity, Brain Function, and Substance Abuse Treatment in Cocaine Dependent Individuals
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|ClinicalTrials.gov Identifier: NCT00217997|
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : May 9, 2017
|Condition or disease|
|Cocaine Abuse Cocaine-Related Disorders|
Cocaine is a strong central nervous system stimulant that is widely abused throughout the United States. Due to its widespread use, it is important to develop an effective treatment for cocaine dependence. The purpose of this study is to determine how impulsivity and prefrontal cortical function are related to treatment response in cocaine dependent individuals.
Participants in this study will complete four separate experiments, each with a different aim and testing panel [cognitive function tests with and without functional magnetic resonance imaging (fMRI)]. The first experiment will examine memory, attention, cognitive function, and impulsivity; the aim is to determine the relationship between impulsivity and cognitive function in cocaine dependent individuals receiving treatment. The second experiment will examine the relationship between impulsivity and the prefrontal cortical structure and function. Participants will complete an fMRI during the second experiment. The third experiment will consist of cognitive function tests and will examine the prefrontal cortex in relation to treatment response, based on four different treatments: 1) L-dopamine, 2) naltrexone, 3) modafinil, and 4) placebo. The fourth experiment will examine the effect of cocaine dependence treatment on prefrontal cortex, focusing on participants receiving modafinil.
|Study Type :||Observational|
|Actual Enrollment :||192 participants|
|Official Title:||Impulsivity, Brain Function and Substance Abuse Treatment|
|Study Start Date :||September 2005|
|Actual Primary Completion Date :||January 2013|
|Actual Study Completion Date :||January 2013|
- fMRI brain activation [ Time Frame: baseline ]Baseline predictor of treatment response
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00217997
|United States, Texas|
|University of Texas Health Science Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Frederick G. Moeller, PhD||University of Texas|