Impulsivity, Brain Function, and Substance Abuse Treatment in Cocaine Dependent Individuals
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this trial is to evaluate aspects of treatment response in cocaine dependent individuals.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Impulsivity, Brain Function and Substance Abuse Treatment|
- fMRI brain activation [ Time Frame: baseline ] [ Designated as safety issue: No ]Baseline predictor of treatment response
|Study Start Date:||September 2005|
|Study Completion Date:||January 2013|
|Primary Completion Date:||January 2013 (Final data collection date for primary outcome measure)|
Cocaine is a strong central nervous system stimulant that is widely abused throughout the United States. Due to its widespread use, it is important to develop an effective treatment for cocaine dependence. The purpose of this study is to determine how impulsivity and prefrontal cortical function are related to treatment response in cocaine dependent individuals.
Participants in this study will complete four separate experiments, each with a different aim and testing panel [cognitive function tests with and without functional magnetic resonance imaging (fMRI)]. The first experiment will examine memory, attention, cognitive function, and impulsivity; the aim is to determine the relationship between impulsivity and cognitive function in cocaine dependent individuals receiving treatment. The second experiment will examine the relationship between impulsivity and the prefrontal cortical structure and function. Participants will complete an fMRI during the second experiment. The third experiment will consist of cognitive function tests and will examine the prefrontal cortex in relation to treatment response, based on four different treatments: 1) L-dopamine, 2) naltrexone, 3) modafinil, and 4) placebo. The fourth experiment will examine the effect of cocaine dependence treatment on prefrontal cortex, focusing on participants receiving modafinil.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00217997
|United States, Texas|
|University of Texas Health Science Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Frederick G. Moeller, PhD||University of Texas|