Evoked Fields After Median and Ulnar Stimulation
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|ClinicalTrials.gov Identifier: NCT00217243|
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : September 18, 2009
|Condition or disease||Intervention/treatment|
|Complex Regional Pain Syndromes||Other: Evoked fields before and after a local block (Xylocaine)|
This study is directed at the (central and / or peripheral) mechanisms of pain and the cortical changes (plasticity) due to chronic non-malignant pain in two groups of patients and one healthy volunteer group.
The aim of the study is further to evaluate cortical processes by MEG (and fMRI, if feasible) to quantify and qualify the responses, localise the generators and study the effects of a pain therapy.
To search for patterns that may result in diagnostic criteria and have an indicative value for the treatment and the monitoring of the effects.
Finally the study not only intends to support clinical diagnosis but also to provide tools to monitor treatment and support the choice (algorithm) between SCS and SAN. An algorithm, facilitating decision making between these two treatments, will be promoted. It should also provide a clinical decision tool for the use of SAN
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||Evoked (Magnetic) Cortical Fields for the Comparative Study of Mechanisms Underlying Chronic Non-malignant Pain in Peripheral Nerve Injury (CRPS II) and CRPS I (Chronic Regional Pain Syndrome I)|
|Study Start Date :||June 2005|
|Actual Study Completion Date :||June 2007|
Pain study Netherlands
20 healthy subjects 20 patients with a traumatic unilateral peripheral nerve injury 20 patients with CRPS I
Other: Evoked fields before and after a local block (Xylocaine)
MEG registration after electrical median and ulnar nerve stimulation in subjects and patients. In the patient group another MEG was performed after an anaesthetic block (1-2 ml Lidocaine 1%) at the site of the nerve injury producing a painfree state
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00217243
|Medical Center of Alkmaar|
|Alkmaar, NH, Netherlands, 1815 JD|
|Principal Investigator:||Peter J Theuvenet, MD||Medical Center Alkmaar|