Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients
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|ClinicalTrials.gov Identifier: NCT00217035|
Recruitment Status : Withdrawn (State of Mass. tightened regulations for making intravenous solutions for research subjects. Study was withdrawn and no participants were enrolled.)
First Posted : September 22, 2005
Last Update Posted : January 13, 2017
Proline is a non-essential amino acid that helps with collagen formation. Collagen is one of the main ingredients of skin, bone, tendons, and connective tissue. It is thought that proline becomes depleted in burn patients because it is being used in greater than normal quantities to help the injured skin and connective tissue heal. If this is true, then the body must look for alternate energy sources as proline becomes depleted.
This study aims to evaluate 1)the metabolic kinetics of the amino acids proline, glutamate, and ornithine and 2) the effects of glutamine supplemented total parenteral nutrition (TPN) on the metabolism of these amino acids.
|Condition or disease||Intervention/treatment|
|Burns||Dietary Supplement: TPN or TPN enriched with glutamine|
Proline is a nutritionally dispensable (non-essential) amino acid. Its synthesis and catabolism is via the pathway of ornithine and glutamate. The latter two amino acids serve as immediate precursors for proline, as well as metabolites. Ornithine is one of the intermediates for urea cycle. Glutamate is metabolically connected to tricarboxylic acid (TCA) cycle, the major cycle for energy production.
It is hypothesized that the significantly increased rates of net nitrogen loss and energy "production", as the consequence of the accelerated activities of both the urea and TCA cycles in burn injury "drain" both ornithine and glutamate, thus depleting tissues of the availability of proline. Hence, the de novo synthesis of proline is likely to be affected by the reduced availability of its major precursors: glutamate and ornithine. We further propose that increased supply of glutamine would increase the de novo synthesis of proline and / or spare the loss of proline via its metabolite glutamate. Hence, glutamine will be beneficial to the overall nutritional status of the burn patients.
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients.|
|Study Start Date :||August 1997|
|Estimated Primary Completion Date :||January 2010|
|Estimated Study Completion Date :||January 2010|
- Dietary Supplement: TPN or TPN enriched with glutamine
Each patient undergoes two nutritional support periods either with or without Glutamine supplementation.Other Names:
- Nutritional Support
- Amino Acid Composition
- This is a study for measuring the protein kinetics for metabolism of the amino acids proline, glutamate, and ornithine. Kinetics will be derived from measurements on blood and air samples taken as part of the study. [ Time Frame: 12 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00217035
|United States, Massachusetts|
|Massachusetts General Hospital Burn Unit|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Ronald G Tompkins, MD, ScD||MGH, Shriners Burn Hospital - Boston|