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Epidemiology and Control of Mansonella Perstans Infection in Uganda

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ClinicalTrials.gov Identifier: NCT00215280
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : April 20, 2007
Sponsor:
Collaborator:
Ministry of Health, Uganda
Information provided by:
DBL -Institute for Health Research and Development

Brief Summary:
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.

Condition or disease Intervention/treatment Phase
Mansonelliasis Pruritus Lymphoedema Abdominal Pains Drug: ivermectin and albendazole Not Applicable

Detailed Description:

Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control

Specific objectives:

  1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
  2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
  3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.

Study Type : Interventional  (Clinical Trial)
Enrollment : 1000 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda
Study Start Date : November 2005
Study Completion Date : February 2006





Primary Outcome Measures :
  1. microfilariae periodicity patterns
  2. epidemiology of M. perstans at community level
  3. clinical spectre among infected
  4. reduction in microfilaraemia

Secondary Outcome Measures :
  1. treatment effect on clinical manifestations


Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Individuals >= 5 years with or without M. perstans infection

Exclusion Criteria:

  • Individuals < 5 years
  • Pregnant women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00215280


Locations
Uganda
Luwero
Luwero and Mukono, Luwero and Mukono Districts, Uganda
Sponsors and Collaborators
DBL -Institute for Health Research and Development
Ministry of Health, Uganda
Investigators
Principal Investigator: Asanta M Asio, Msc Ministry of Health, Uganda

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00215280     History of Changes
Other Study ID Numbers: MV917090205
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: April 20, 2007
Last Verified: April 2007

Keywords provided by DBL -Institute for Health Research and Development:
Mansonella perstans
microfilaraemia
ivermectin
albendazole
Uganda

Additional relevant MeSH terms:
Dipetalonema Infections
Acanthocheilonemiasis
Lymphedema
Abdominal Pain
Pruritus
Mansonelliasis
Lymphatic Diseases
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Signs and Symptoms, Digestive
Skin Diseases
Skin Manifestations
Filariasis
Spirurida Infections
Secernentea Infections
Nematode Infections
Helminthiasis
Parasitic Diseases
Albendazole
Ivermectin
Anthelmintics
Antiparasitic Agents
Anti-Infective Agents
Anticestodal Agents
Antiplatyhelmintic Agents
Antiprotozoal Agents
Tubulin Modulators
Antimitotic Agents