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Epidemiology and Control of Mansonella Perstans Infection in Uganda

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00215280
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : April 20, 2007
Ministry of Health, Uganda
Information provided by:
DBL -Institute for Health Research and Development

Brief Summary:
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.

Condition or disease Intervention/treatment Phase
Mansonelliasis Pruritus Lymphoedema Abdominal Pains Drug: ivermectin and albendazole Not Applicable

Detailed Description:

Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control

Specific objectives:

  1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
  2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
  3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 1000 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda
Study Start Date : November 2005
Study Completion Date : February 2006

Primary Outcome Measures :
  1. microfilariae periodicity patterns
  2. epidemiology of M. perstans at community level
  3. clinical spectre among infected
  4. reduction in microfilaraemia

Secondary Outcome Measures :
  1. treatment effect on clinical manifestations

Information from the National Library of Medicine

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Ages Eligible for Study:   5 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Individuals >= 5 years with or without M. perstans infection

Exclusion Criteria:

  • Individuals < 5 years
  • Pregnant women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00215280

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Luwero and Mukono, Luwero and Mukono Districts, Uganda
Sponsors and Collaborators
DBL -Institute for Health Research and Development
Ministry of Health, Uganda
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Principal Investigator: Asanta M Asio, Msc Ministry of Health, Uganda
Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00215280    
Other Study ID Numbers: MV917090205
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: April 20, 2007
Last Verified: April 2007
Keywords provided by DBL -Institute for Health Research and Development:
Mansonella perstans
Additional relevant MeSH terms:
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Dipetalonema Infections
Abdominal Pain
Lymphatic Diseases
Skin Diseases
Skin Manifestations
Neurologic Manifestations
Signs and Symptoms, Digestive
Spirurida Infections
Secernentea Infections
Nematode Infections
Parasitic Diseases
Antiparasitic Agents
Anti-Infective Agents
Anticestodal Agents
Antiplatyhelmintic Agents
Antiprotozoal Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action