Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

TWIST Human Gene and Cleft Lips and Palates

This study has been terminated.
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT00213889
First received: September 13, 2005
Last updated: March 26, 2015
Last verified: March 2015
  Purpose
This study uses a sequence analysis for TWIST and other craniofacial development genes, among patients presenting with facial clefting.

Condition Intervention
Cleft Lip
Other: None: molecular genetics diagnosis procedure only

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: TWIST Human Gene and Cleft Lips and Palates

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Primary Outcome Measures:
  • to show, among patients displaying facial clefting, the TWIST mutations and the mutation in genes involved with TWIST in craniofacial development [ Time Frame: Not relevant ]

Secondary Outcome Measures:
  • to show, among patients displaying facial clefting and mutations in such genes, possible mutations in the same genes [ Time Frame: Not relevant ]

Enrollment: 45
Study Start Date: February 2003
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: None: molecular genetics diagnosis procedure only
    None: molecular genetics diagnosis procedure only
  Eligibility

Ages Eligible for Study:   1 Month and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Patients aged from 1 month to 18 years:

  • Parents agree to enrollment or patients, themselves, agree to enrollment when able to do so
  • Healthcare insurance holders
  • Display facial clefting

Grown patients over 18 years of age:

  • Agree to enrollment
  • Display facial clefting
  • Healthcare insurance holders

Exclusion Criteria:

  • Patients declining enrollment
  • Patients without healthcare insurance
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00213889

Locations
France
Centre d'Investigations Cliniques, Hôpital Civil, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091
Centre de Soins , d'Enseignement et de Recherche Dentaire (CESRD), Hôpital Civil, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091
Service de Chirurgie Infantile, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67098
Service de Consultation de la Face, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67098
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
Principal Investigator: Pascal TSCHILL, MD Laboratoire de Génétique Molécules des Eucaryotes (LGME)
  More Information

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00213889     History of Changes
Other Study ID Numbers: 2602
Study First Received: September 13, 2005
Last Updated: March 26, 2015

Keywords provided by University Hospital, Strasbourg, France:
Facial clefting
twist
craniofacial development genes
Human cleft lip and palate
cleft lip and palate

Additional relevant MeSH terms:
Cleft Lip
Lip Diseases
Mouth Diseases
Stomatognathic Diseases
Mouth Abnormalities
Stomatognathic System Abnormalities
Congenital Abnormalities

ClinicalTrials.gov processed this record on April 21, 2017