myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies (MYOARRAY)
The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care.
Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies.
Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.
|Polymyositis Dermatomyositis||Other: transcriptome analysis Other: T cell repertoire analysis|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
|Official Title:||Transcriptome Analysis Through a Dedicated Macro-array and TcLandscape Repertoire Analysis for Diagnosis of Myositis.|
- transcriptome [ Time Frame: at inclusion ]
|Study Start Date:||November 2004|
|Study Completion Date:||July 2010|
|Primary Completion Date:||July 2010 (Final data collection date for primary outcome measure)|
Other: transcriptome analysis
transcriptome analysis from muscle biopsyOther: T cell repertoire analysis
blood T cell repertoire analysis
Please refer to this study by its ClinicalTrials.gov identifier: NCT00213629
|University Hospital of Rouen|
|Rouen, Seine Maritime, France, 76000|
|Principal Investigator:||Olivier Boyer, MD, PhD||University Hospital, Rouen|